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Kidney cancer: Conservative surgery not inferior to nephrectomy, study suggests

Date:
April 19, 2010
Source:
European Association of Urology
Summary:
New results suggests that conservative surgery is not inferior to radical renal surgery or nephrectomy.
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The latest results from the European Organisation for Research and Treatment of Cancer (EORTC) 30904 study were presented in a plenary session April 19 at the Anniversary EAU Congress, which showed that conservative surgery is not inferior to radical renal surgery or nephrectomy.

"Few patients progressed during the study, nine in the radical arm and 12 in the conservative arm," Prof. Hein van Poppel said in his concluding remarks. Van Poppel issued the EORTC results during the plenary session on kidney cancer, a study which examined partial versus radical nephrectomy in renal cancer.

The EORTC 30904 study involved 541 patients who were randomised, 273 in the radical arm and 268 treated with conservative surgery. Four patients were clinically ineligible, whilst 139 patients were pathologically ineligible. The median follow-up was around 9.3 years.

Amongst the study's pertinent findings were:

  • Few patients progressed during the study, nine in the radical arm and 12 in the conservative arm
  • 117 deaths

12 due to RCC: 4 in radical and 8 in conservative

3 due to surgery: 1 in radical and 2 in conservative

  • Overall survival (OS) is shorter on the conservative arm for all randomized patients (p=0.032)
  • OS of RCC patients is not different (p=0.072)
  • OS of Clinically and pathologically eligible patients is not different (p=0.173)
  • Side effects: nephron-sparing surgery is safe with a slightly higher complication rate than after radical nephrectomy

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The above post is reprinted from materials provided by European Association of Urology. Note: Materials may be edited for content and length.


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European Association of Urology. "Kidney cancer: Conservative surgery not inferior to nephrectomy, study suggests." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419090952.htm>.
European Association of Urology. (2010, April 19). Kidney cancer: Conservative surgery not inferior to nephrectomy, study suggests. ScienceDaily. Retrieved July 3, 2015 from www.sciencedaily.com/releases/2010/04/100419090952.htm
European Association of Urology. "Kidney cancer: Conservative surgery not inferior to nephrectomy, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419090952.htm (accessed July 3, 2015).

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