Featured Research

from universities, journals, and other organizations

Exercise can forestall osteoporosis

Date:
May 8, 2010
Source:
Medical College of Georgia
Summary:
The stage for osteoporosis is set well before menopause -- but exercise can help rewrite the script, according to researchers. They hypothesize that higher levels of follicle-stimulating hormone decrease bone mineral density by influencing the production of cytokines.

Dr. Joseph Cannon.
Credit: Image courtesy of Medical College of Georgia

The stage for osteoporosis is set well before menopause -- but exercise can help rewrite the script, according to Medical College of Georgia researchers.

Declining estrogen levels have long been associated with osteoporosis, but bone density starts to decline years before these levels drop, according to Dr. Joseph Cannon, Kellet Chair in Allied Health Sciences and principal investigator of the National Institute of Aging-funded study. It's during that time that levels of follicle-stimulating hormone, released by the pituitary gland to help regulate ovarian function, actually increase.

Cannon theorizes that higher levels of FSH decrease bone mineral density by increasing cytokines, regulatory proteins produced by white blood cells. One cytokine in particular, interleukin-1, signals certain cells to transform into osteoclasts, which break down and resorb bone. "We hypothesize that the higher levels of FSH decrease bone mineral density by influencing the production of cytokines," said Cannon, who presented his team's research at the American Physiological Society's Experimental Biology 2010 conference in Anaheim, Calif. (April 24-28).

After measuring FSH and bone mineral density in 36 women between the ages of 20 to 50, the researchers correlated higher FSH levels with lower bone mineral density. When they incubated FSH with white blood cells isolated from the women, it stimulated production of interleukin-1. Moreover, higher circulating levels of IL-1 correlated with lower bone mineral density, if the levels of interleukin-1 inhibitory factors were taken into account.

Additionally, they found that study participants who exercised more than 180 minutes a week retained greater bone density.

"Our work provides more evidence that physical activity is important for maintaining bone density. It's a case of 'use it or lose it,'" Cannon said, citing his team's findings that exercise seemed to promote inhibitory factors that help keep interleukin-1 and bone breakdown under control.

The team's next step is to determine how exercise influences the expression of interleukin-1 inhibitory factors.

Team members include Dr. Miriam Cortez-Cooper, assistant professor of physical therapy; Eric Meaders, assistant professor of biomedical and radiological technologies; Judith Stallings, assistant professor of physician assistant; Sara Haddow, assistant professor of physician assistant; Barbara Kraj, assistant professor of biomedical and radiological technologies; Gloria Sloan, research associate; and Dr. Anthony Mulloy, section chief of endocrinology and nutrition.


Story Source:

The above story is based on materials provided by Medical College of Georgia. Note: Materials may be edited for content and length.


Cite This Page:

Medical College of Georgia. "Exercise can forestall osteoporosis." ScienceDaily. ScienceDaily, 8 May 2010. <www.sciencedaily.com/releases/2010/04/100426105643.htm>.
Medical College of Georgia. (2010, May 8). Exercise can forestall osteoporosis. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/04/100426105643.htm
Medical College of Georgia. "Exercise can forestall osteoporosis." ScienceDaily. www.sciencedaily.com/releases/2010/04/100426105643.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins