Featured Research

from universities, journals, and other organizations

Extracapsular lymph node involvement: A negative prognostic factor for esophageal cancer

Date:
April 28, 2010
Source:
World Journal of Gastroenterology
Summary:
The presence and extent of lymphatic dissemination are among the most important predictors for survival in gastrointestinal malignancies. Little is known about the effects of neoadjuvant chemoradiotherapy (CRT) on the presence of extracapsular lymph node involvement (LNI) and its prognostic value in patients with resected esophageal cancer. Researchers have now found that extracapsular LNI is not influenced by neoadjuvant CRT.

There is increasing evidence to include combined neoadjuvant chemoradiotherapy (CRT) as an alternative to surgical resection alone, to improve survival for locoregional esophageal cancer. More recently, attention has focused on the presence of extracapsular lymph node involvement (LNI), which identifies a subgroup of patients with significantly worse long-term survival. Little is known about the effects of neoadjuvant chemoradiotherapy (CRT) on the presence of extracapsular LNI and its prognostic value in patients with resected esophageal cancer.

Related Articles


A research article to be published in April 28, 2010 in the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Metzger R and Dr. Hölscher AH from the Department of General, Visceral, and Cancer Surgery, Center for Integrated Oncology, University of Cologne, Germany investigated the effects of neoadjuvant CRT on the presence of extracapsular LNI and its prognostic value in patients with resected esophageal cancer. Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy, of whom 68.8% were treated with neoadjuvant CRT prior to resection. A total of 986 metastatic LNs were examined.

The results support the hypothesis that extracapsular LNI is not influenced by neoadjuvant CRT and identifies a subgroup of esophageal cancer patients with a significantly worse long-term survival. Therefore extracapsular LNI should be noted as a negative prognostic factor and should be taken into account for a revised staging system for esophageal cancer.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Metzger R, Bollschweiler E, Drebber U, Mönig SP, Schröder W, Alakus H, Kocher M, Baldus SE, Hölscher AH. Neoadjuvant chemoradiotherapy for esophageal cancer: Impact on extracapsular lymph node involvement. World Journal of Gastroenterology, 2010; 16 (16): 1986 DOI: 10.3748/wjg.v16.i16.1986

Cite This Page:

World Journal of Gastroenterology. "Extracapsular lymph node involvement: A negative prognostic factor for esophageal cancer." ScienceDaily. ScienceDaily, 28 April 2010. <www.sciencedaily.com/releases/2010/04/100428093933.htm>.
World Journal of Gastroenterology. (2010, April 28). Extracapsular lymph node involvement: A negative prognostic factor for esophageal cancer. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2010/04/100428093933.htm
World Journal of Gastroenterology. "Extracapsular lymph node involvement: A negative prognostic factor for esophageal cancer." ScienceDaily. www.sciencedaily.com/releases/2010/04/100428093933.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Diné Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins