Featured Research

from universities, journals, and other organizations

Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction

Date:
May 15, 2010
Source:
University of Texas Medical Branch at Galveston
Summary:
Researchers have determined that moderately and temporarily restricting the flow of blood through muscles -- a practice adopted by bodybuilders who noticed that it made light weights feel heavier -- can be combined with low-level resistance exercise training to produce muscle-mass increases in older men.

For years, researchers have known that resistance exercise training -- such as weightlifting, in which muscles work against gravity or another force -- can be one of the most effective ways to fight the debilitating muscle loss caused by aging.

But many older people are unable to get the full benefits of such training because they suffer from conditions such as arthritis that prevent them from lifting enough weight to stimulate muscle growth. And, while younger men and women continue to produce significant amounts of muscle protein for hours after a resistance exercise workout, seniors receive a much smaller post-workout benefit.

Now, though, University of Texas Medical Branch at Galveston researchers have determined that moderately and temporarily restricting the flow of blood through muscles -- a practice adopted by bodybuilders who noticed that it made light weights feel heavier -- can be combined with low-level resistance exercise training to produce muscle-mass increases in older men.

"We think that this may be a novel treatment for older people who need to bring their muscle mass back up," said UTMB physical therapy professor Blake Rasmussen, senior author of a paper on the investigation appearing in the May issue of the Journal of Applied Physiology. "It could also be used for patients who have had surgery and aren't capable of lifting enough weight to keep their muscles in shape, or for people who have arthritis or other conditions that make lifting heavy weights a problem."

The UTMB investigators studied changes in the thigh muscles of seven older men (average age 70) when they performed four minutes of low-resistance leg extension exercises both with and without inflatable cuffs that reduced blood flow out of the muscles. Muscle protein synthesis was measured in each of the men by monitoring changes in a chemical tracer infused into the bloodstream. In addition, a series of biopsies yielded muscle samples that were analyzed to track alterations in biochemical pathways critical to muscle growth.

"We saw that when we put the cuffs on, they responded similarly to young people doing traditional high-intensity resistance exercise," said UTMB graduate student Christopher Fry, the lead author of the paper. "The low-intensity exercise produced increases in protein synthesis, and activated two cellular pathways that stimulate protein synthesis and muscle growth in the post-exercise period."

Exactly how restricting blood flow in the muscles generated these effects remains unknown, although Rasmussen and Fry speculated that either an improved ability to activate Type II muscle fibers or a response to the sudden surge of blood into the muscles when the cuffs were released could be responsible. Whatever the mechanism, Rasmussen said, "we think it's an exciting potential new rehabilitation tool."

"You could use this following ACL knee surgery or hip fracture surgery, for example," Rasmussen said. "In the first few weeks after ACL surgery, the joint just won't allow you to lift heavy weight. So instead, you could use a really light weight with a restriction cuff, which may prevent the muscle loss that you normally see following knee surgery."

Other authors of the paper included graduate student Erin Glynn, assistant professor Micah Drummond, postdoctoral fellow Kyle Timmerman, research scientist Shaheen Dhanani and professor Elena Volpi, as well as Satoshi Fujita and Takashi Abe of the University of Tokyo. The National Institute of Arthritis and Musculoskeletal and Skin Diseases, UTMB's Institute for Translational Sciences Clinical Research Center, the UTMB Center for Rehabilitation Sciences and Sato Sports Plaza provided support for this research.


Story Source:

The above story is based on materials provided by University of Texas Medical Branch at Galveston. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. S. Fry, E. L. Glynn, M. J. Drummond, K. L. Timmerman, S. Fujita, T. Abe, S. Dhanani, E. Volpi, B. B. Rasmussen. Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. Journal of Applied Physiology, 2010; 108 (5): 1199 DOI: 10.1152/japplphysiol.01266.2009

Cite This Page:

University of Texas Medical Branch at Galveston. "Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction." ScienceDaily. ScienceDaily, 15 May 2010. <www.sciencedaily.com/releases/2010/05/100514151926.htm>.
University of Texas Medical Branch at Galveston. (2010, May 15). Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2010/05/100514151926.htm
University of Texas Medical Branch at Galveston. "Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction." ScienceDaily. www.sciencedaily.com/releases/2010/05/100514151926.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins