Featured Research

from universities, journals, and other organizations

What is the best treatment for children with vesicoureteral reflux?

Date:
May 20, 2010
Source:
Elsevier Health Sciences
Summary:
Children with vesicoureteral reflux, in which urine flows backwards into the kidneys from the bladder, have been treated in the past with surgery or antibiotic therapy. Although this condition can lead to renal damage, there have been few controlled studies to help determine the most effective treatment of young children.

Children with vesicoureteral reflux (VUR), in which urine flows backwards into the kidneys from the bladder, have been treated in the past with surgery or antibiotic therapy. Although this condition can lead to renal damage, there have been few controlled studies to help determine the most effective treatment of young children. A study, part of the Swedish Reflux Trial, is scheduled for publication in the July 2010 issue of the Journal of Urology.

Related Articles


Investigators from the Pediatric Uro-Nephrologic Center, The Queen Silvia Children's Hospital, University of Gothenburg, Sweden, led a national study in which 203 children with VUR were followed in a randomized clinical trial (128 girls and 75 boys). One-third received prophylactic antibiotics, one-third received endoscopic intervention and one-third was observed with no treatment.

"Controlled studies are needed to provide an evidence base for treatment in children with VUR," according to lead investigator Sverker Hansson, MD. "The Swedish Reflux Trial was set up as a RCT to compare long-term antibiotic prophylaxis, endoscopic correction and surveillance as the control group in children with dilating VUR in regard to the febrile UTI rate, and kidney and VUR status at 2 years. Secondary outcomes were complications and the impact of factors such as VUR grade, gender and bladder dysfunction. In the current report we analyzed the progression of renal defects present at entry and the development of new renal damage in the 3 treatment groups."

The researchers found that the rate of new renal damage in boys was low, with only one boy who received endoscopic treatment and one on surveillance having further damage. In girls the rate was higher (13 or 10%) and there was a significant difference between treatment groups with new damage most common in controls on surveillance. New damage was observed in 19% of girls on surveillance, 12% who received endoscopic treatment and in none on prophylaxis.

There was a strong association between recurrent febrile urinary tract infections (UTI) and new renal damage in girls but recurrent UTIs and new damage were unusual in boys. The febrile UTI rate differed significantly between treatment groups in girls, including a recurrence rate of 57% in the surveillance, 23% in the endoscopic and 19% in the prophylactic groups.

Dr. Hansson and co-investigators state, "An interesting finding was that new damage as well as the progression of previously observed renal uptake defects was only seen in kidneys drained by ureters with dilating VUR with 1 exception. There was no difference in this respect whether VUR was grade III or IV at study entry. Previously unscarred kidneys were as vulnerable to new renal damage as those with uptake defects at entry."


Story Source:

The above story is based on materials provided by Elsevier Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Per Brandstrφm, Tryggve Nevιus, Rune Sixt, Eira Stokland, Ulf Jodal and Sverker Hansson. The Swedish Reflux Trial in Children: IV. Renal Damage. The Journal of Urology, 2010; (in press)

Cite This Page:

Elsevier Health Sciences. "What is the best treatment for children with vesicoureteral reflux?." ScienceDaily. ScienceDaily, 20 May 2010. <www.sciencedaily.com/releases/2010/05/100520102915.htm>.
Elsevier Health Sciences. (2010, May 20). What is the best treatment for children with vesicoureteral reflux?. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2010/05/100520102915.htm
Elsevier Health Sciences. "What is the best treatment for children with vesicoureteral reflux?." ScienceDaily. www.sciencedaily.com/releases/2010/05/100520102915.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) — The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) — Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins