Featured Research

from universities, journals, and other organizations

Growth hormone safe for infants with chronic kidney failure, study finds

Date:
June 7, 2010
Source:
American Society of Nephrology
Summary:
Infants with chronic renal failure (CRF) grow slowly, a problem that usually improves with aggressive nutritional therapy. When it doesn't, growth hormone is a safe and effective treatment to promote growth, according to a new study.

Infants with chronic renal failure (CRF) grow slowly, a problem that usually improves with aggressive nutritional therapy. When it doesn't, growth hormone is a safe and effective treatment to promote growth, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

Related Articles


"Early treatment with growth hormone improves growth retardation and bone mineral density without short-term undesirable effects," comments Fernando Santos, MD, PhD (Hospital Universitario Central de Asturias, Oviedo, Spain).

The Spanish-Portuguese multicenter collaborative study included 16 infants with CRF who had continued growth retardation despite nutritional therapy. All infants were receiving dialysis or other conservative treatments for their chronic kidney disease.

One group of infants received growth hormone while the other did not. During the yearlong study, infants treated with growth hormone grew an average of 5.7 inches, compared to 3.7 inches in those who did not receive growth hormone.

Equally important, growth hormone caused no harmful effects such as early bone maturation, progression of kidney disease, or metabolic abnormalities. Several key indicators of nutrition and bone growth were similar between groups.

Some infants with CRF do not grow, despite receiving good nutrition and treatment to control other factors that can lead to growth problems. The new results show that, for these uncommon cases, growth hormone therapy can be effective. "Growth hormone is an additional tool to avoid aggravation of growth impairment in this group of patients," says Santos.

In some countries -- including Spain and Portugal -- growth hormone is not approved for use in children less than two years old. By that time, children with CRF may already have an important delay in growth, according to Santos.

Even in countries where growth hormone is approved for the treatment of growth failure in young children (including the United States), doctors and parents may be reluctant to use it. "Our study supports early treatment with GH in those infants with CRF who remain growth retarded after achieving good clinical, metabolic and nutritional control," Santos and coauthors conclude.

Santos adds that further follow-up would provide interesting data on the long-term evolution of growth and on the progression of kidney failure.

The study was a clinical trial sponsored by Novo Nordisk.

Study co-authors were M. Llanos Moreno (Novo Nordisk Pharma SA, Spain), Arlete Neto (Hospital Dona Estefânia, Lisboa, Portugal), Gema Ariceta (Hospital de Cruces, Baracaldo, Spain), Julia Vara, Rafael Muley (Hospital 12 de Octubre, Madrid), Angel Alonso (Hospital Universitario Infantil La Paz, Madrid), Alberto Bueno (Hospital Universitario Materno Infantil, Complejo Hospitalario Carlos Haya, Málaga, Spain), Alberto Caldas Afonso (Hospital de Săo Joăo, Porto, Portugal), António Jorge Correia (Hospital Pediátrico de Coimbra, Portugal), Vicente Barrios, Jesús Argente (Hospital Infantil Universitario Nińo Jesús, Universidad Autónoma de Madrid), and Carlos Gómez (Hospital Universitario Central de Asturias).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fernando Santos, M. Llanos Moreno, Arlete Neto, Gema Ariceta, Julia Vara, Angel Alonso, Alberto Bueno, Alberto Caldas Afonso, Antonio Jorge Correia, Rafael Muley, Vicente Barrios, Carlos Gomez, Jesus Argente. Improvement in Growth After 1 Year of Growth Hormone Therapy in Well-Nourished Infants with Growth Retardation Secondary to Chronic Renal Failure: Results of a Multicenter, Controlled, Randomized, Open Clinical Trial. Clinical Journal of the American Society of Nephrology, 2010; DOI: 10.2215/CJN.07791109

Cite This Page:

American Society of Nephrology. "Growth hormone safe for infants with chronic kidney failure, study finds." ScienceDaily. ScienceDaily, 7 June 2010. <www.sciencedaily.com/releases/2010/06/100603172117.htm>.
American Society of Nephrology. (2010, June 7). Growth hormone safe for infants with chronic kidney failure, study finds. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2010/06/100603172117.htm
American Society of Nephrology. "Growth hormone safe for infants with chronic kidney failure, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/06/100603172117.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) — A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) — With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) — If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins