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Blueberry ameliorates hepatic fibrosis, study finds

Date:
June 18, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from China examined the effect of blueberry on hepatic fibrosis and detoxification enzyme systems in rats. The results demonstrated that blueberry has a therapeutic effect on CCl4-induced hepatic fibrosis by reducing hepatocyte injury and lipid peroxidation.

Conventional drugs used in the treatment of liver diseases inevitably have side effects. An increasing number of natural substances have been studied to explore if they have protective effects on the liver. Blueberries have unique effects on human retinal, brain and tumor cells, but reports about the effects of blueberries on liver diseases are lacking.

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A research article to be published on June 7, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Ming-Liang Cheng, MD, from Department of Infectious Diseases, Guiyang Medical College, Guiyang, presented some data from their research on the effectiveness of blueberries on liver fibrosis induced in laboratory animals.

Their study showed that blueberries could reduce liver indices, serum levels of hyaluronic acid and alanine aminotransferase, and increase levels of superoxide dismutase and decrease levels of malondialdehyde in liver homogenates compared with the model group. Meanwhile, the stage of hepatic fibrosis was significantly weakened. Blueberries increased the activity of glutathione-S-transferase in liver homogenates and the expression of Nrf2 and Nqo1 compared with the normal group, but there was no significant difference compared with the model group.

The authors suggest that blueberry consumption is beneficial for hepatic diseases (including fibrosis).


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wang YP, Cheng ML, Zhang BF, Mu M, Wu J. Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroenterol, 2010; 16 (21): 2657-2663 [link]

Cite This Page:

World Journal of Gastroenterology. "Blueberry ameliorates hepatic fibrosis, study finds." ScienceDaily. ScienceDaily, 18 June 2010. <www.sciencedaily.com/releases/2010/06/100617102706.htm>.
World Journal of Gastroenterology. (2010, June 18). Blueberry ameliorates hepatic fibrosis, study finds. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2010/06/100617102706.htm
World Journal of Gastroenterology. "Blueberry ameliorates hepatic fibrosis, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/06/100617102706.htm (accessed March 30, 2015).

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