Featured Research

from universities, journals, and other organizations

Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization

Date:
July 19, 2010
Source:
Journal of Clinical Investigation
Summary:
Although approaches such as IVF are commonly used in developed countries to treat infertile couples, the processes remain relatively inefficient. Better understanding of events such as embryo development prior to implantation could help improve the efficiency of IVF. In this context, researchers have now determined that the protein Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization and culture.

Infertility affects approximately 10% of couples worldwide. Although assisted reproductive technologies such as in vitro fertilization are commonly used in developed countries to treat infertile couples, the processes remain relatively inefficient.

Better understanding of events such as embryo development prior to implantation, a time when many potential natural pregnancies fail, could help improve the efficiency of assisted reproductive technologies.

In this context, a team of researchers, led by Hiroki Kurihara, at the University of Tokyo, Japan, has now determined that the protein Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization and culture. Of potential clinical significance, the negative effects of Sirt3 inactivation on mouse embryos could be overcome by culture in the presence of an antioxidant or in low oxygen conditions.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kawamura et al. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42020

Cite This Page:

Journal of Clinical Investigation. "Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization." ScienceDaily. ScienceDaily, 19 July 2010. <www.sciencedaily.com/releases/2010/07/100719124404.htm>.
Journal of Clinical Investigation. (2010, July 19). Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2010/07/100719124404.htm
Journal of Clinical Investigation. "Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization." ScienceDaily. www.sciencedaily.com/releases/2010/07/100719124404.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins