Featured Research

from universities, journals, and other organizations

Natural substance NT-020 aids aging brains in rats, study finds

Date:
July 21, 2010
Source:
University of South Florida (USF Health)
Summary:
Researchers found that a combination of nutrients called NT-020 promoted adult neural stem cell proliferation in aged rats and boosted their memory and spatial navigation performance. They tested two groups of aged laboratory rats; one group received NT-020 and a control group did not. In the NT-020 treated group, neurogenesis increased and researchers concluded that the NT-020 treated group had fewer activated inflammatory brain cells and an increase in stem cells.

A combination of nutrients called NT-020 promoted adult neural stem cell proliferation in aged rats and boosted their memory performance, reported University of South Florida researchers studying natural therapeutic approaches to promoting the health of neurons in the aging brain.

Researchers from the USF Department of Neurosurgery and Brain Repair tested two groups of aged laboratory rats; one group received NT-020 and another, the control group, did not. In the NT-020 group, the process by which neurons are generated -- called neurogenesis -- increased.

The study was published in the current issue of Rejuvenation Research (Vol. 13 No. 5, June, 2010). The NT-020 formula was patented by USF and licensed to Natura Therapeutics, Inc.

"Aging has been linked to oxidative stress, and we have previously shown that natural compounds made from blueberries, green tea, and amino acids, such as carnosine, are high in antioxidants and have anti-inflammatory and anti-oxidative activity," said Sandra Acosta, MS, the study's lead author and a PhD student in the USF Center of Excellence in Aging and Brain Repair . "The combination of these nutrients, called NT-020, creates a synergistic effect that promotes the proliferation of stem cells in the aged animals."

Acosta and colleagues compared the NT-020 group to the control group by evaluating their performance on a variety of behavioral and memory tests, including a spatial navigation test. The NT-020 group demonstrated increased adult neural stem cell proliferation in the two main stem cell niches in the brains and improvement in learning and memory.

In past studies, NT-020 has been shown to have beneficial effects on animals with simulated stroke. NT-020 has also been shown to encourage the proliferation of adult stem cells, which have the potential to develop into tissue and bone cells and also migrate to areas of damage to help with repair.

That increased stem cell proliferation coincided with better cognitive performance is significant.

"The notion that aging is a stem cell disease has been gaining popularity," said study senior author Paula Bickford, PhD, professor of neurosurgery and brain repair at USF and a senior research career scientist at the James A. Haley Veterans' Hospital (Tampa). "Our hypothesis is that aging alters the local environment in the brain and other organs and can promote an environment that retards the growth of stem cells. For example, high glucose, which would be seen with diabetes, excessive alcohol and oxidative stress, can lead to reduced neurogenesis."

The researchers concluded that increased inflammation in the brains of the aged animals led to reduced production of stem cells, but that stem cell renewal created a rejuvenating effect. They found that NT-020 treated animals had fewer activated inflammatory cells in the brain, reflecting a decrease in factors that reduced the production of stem cells.

"NT-020 may have not only a positive effect on the stem cell niche," concluded Bickford. "NT-020 may have far-reaching effects on organ function beyond the replacement of injured cells, as demonstrated by cognitive improvement in the NT-020 group."

Disclaimer statement: Paula Bickford and Paul Sanberg are co-founders of Natura Therapeutics, Inc.


Story Source:

The above story is based on materials provided by University of South Florida (USF Health). The original article was written by Randolph Fillmore, USF Center of Excellence for Aging and Brain Repair. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Acosta, J. Jernberg, C.D. Sanberg, P.R. Sanberg, Brent J. Small, Carmelina Gemma, Paula C. Bickford. NT-020, a Natural Therapeutic Approach to Optimize Spatial Memory Performance and Increase Neural Progenitor Cell Proliferation and Decrease Inflammation in the Aged Rat. Rejuvenation Research, 2010; 100629131832013 DOI: 10.1089/rej.2009.1011

Cite This Page:

University of South Florida (USF Health). "Natural substance NT-020 aids aging brains in rats, study finds." ScienceDaily. ScienceDaily, 21 July 2010. <www.sciencedaily.com/releases/2010/07/100720083201.htm>.
University of South Florida (USF Health). (2010, July 21). Natural substance NT-020 aids aging brains in rats, study finds. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/07/100720083201.htm
University of South Florida (USF Health). "Natural substance NT-020 aids aging brains in rats, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/07/100720083201.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins