Featured Research

from universities, journals, and other organizations

Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype

Date:
October 3, 2010
Source:
American Association for Cancer Research
Summary:
Puerto Rican women who had breast cancer that lacked estrogen and progesterone receptors and did not overexpress the HER2neu protein (triple-negative) had worse survival than those with other types of invasive breast cancer, according to a new study.

Puerto Rican women who had breast cancer that lacked estrogen and progesterone receptors and did not overexpress the HER2neu protein (triple-negative) had worse survival than those with other types of invasive breast cancer, according to a study presented at the Third AACR Conference on The Science of Cancer Health Disparities, held Sept. 30 -- Oct. 3, 2010.

"As the incidence of breast cancer rises in Puerto Rico, following U.S. trends, it is important to understand the association of disease subtypes with survival," said Ana P. Ortiz Martinez, M.P.H., Ph.D., associate professor and researcher at the University of Puerto Rico Cancer Center and the department of biostatistics and epidemiology, Graduate School of Public Health, University of Puerto Rico. "Breast cancer is a complex disease, with distinct subtypes with widely differing therapeutic indications and clinical outcomes."

This is the first published study on the impact of tumor subtypes and other clinical factors on breast cancer survival in Puerto Rico.

Researchers analyzed data for 974 female patients with invasive breast cancer who were diagnosed and treated in two main hospitals in Puerto Rico from 2000 to 2005.

The risk of breast cancer death for Puerto Rican women who had the triple-negative breast cancer subtype was more than twice as high as women with other tumor subtypes, even after accounting for a woman's age and cancer stage at diagnosis.

Women who were 50 years old or younger at the time of diagnosis and had regional/distant disease were also more likely to die as a result of their breast cancer.

Of the women studied, 22.5 percent had breast cancer that was HER2neu-positive (meaning that it overexpressed this protein); 60.9 percent of the breast cancers were positive for estrogen or progesterone receptors, but negative for HER2neu; and 16.6 percent were triple negative, neither overexpressing HER2neu nor receptive to estrogen or progesterone.

Findings, which were consistent with results described in previous studies of U.S. populations, will be useful in the development of cancer control strategies in Puerto Rico and may have an impact on future studies of targeted therapies to improve breast cancer survival in other Hispanic populations, said Ortiz Martinez.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype." ScienceDaily. ScienceDaily, 3 October 2010. <www.sciencedaily.com/releases/2010/10/101003081621.htm>.
American Association for Cancer Research. (2010, October 3). Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/10/101003081621.htm
American Association for Cancer Research. "Decreased survival for Puerto Rican women with 'triple-negative' breast cancer subtype." ScienceDaily. www.sciencedaily.com/releases/2010/10/101003081621.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins