Featured Research

from universities, journals, and other organizations

ADHD more common in offspring of mothers with genetic serotonin deficiencies

Date:
October 5, 2010
Source:
JAMA and Archives Journals
Summary:
Children whose mothers are genetically predisposed to have impaired production of serotonin appear more likely to develop attention-deficit hyperactivity disorder later in life, according to a new report.

Children whose mothers are genetically predisposed to have impaired production of serotonin appear more likely to develop attention-deficit hyperactivity disorder (ADHD) later in life, according to a report in the October issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Related Articles


"Serotonin is a hormone and transmitter that performs a broad range of physiological functions in the human body," the authors write as background information in the article. "In addition to its transmitter function in the mature nervous system, serotonin has an important role during development"; it is involved in the formation and differentiation of neurons, their migration to their proper position and the arrangement of the synapses between them. The human genome encodes two enzymes involved in the biosynthesis of serotonin; previous studies have suggested alterations in these genes or enzymes in pregnant females could result in birth defects.

Anne Halmψy, M.D., of University of Bergen, Norway, and colleagues studied 459 adult outpatients with ADHD, 97 of their family members and 187 control individuals recruited from across Norway. Participants provided blood samples for gene sequencing along with information about psychiatric diagnoses and symptoms.

By sequencing 646 individuals, the researchers identified nine different mutations, of which eight were significantly associated with impaired function of the enzymes. Family analysis of 38 individuals who carried these mutations and 41 of their offspring revealed that children of mothers who had one of the mutations -- and, therefore, had impaired serotonin production -- had a 1.5- to 2.5-time higher risk of ADHD than control individuals or offspring of fathers with the mutations.

There was a large variance in the number and severity of symptoms reported by these individuals, suggesting that for offspring of mothers with these mutations, "the clinical outcome probably depends on a sum of many different genetic or environmental factors in addition to variations in maternal serotonin levels."

The results may have public health implications, the authors note. "Whether it is caused by genetic vulnerability, chronic inflammation, malnutrition or other processes, maternal serotonin deficiency during pregnancy might predispose to neuropsychiatric disorders and cardiovascular illnesses," they conclude. "However, further replication studies, preferably in larger samples, will be required to corroborate this relationship."

This study was supported by the Research Council of Norway, Western Norway Regional Health Authority and the University of Bergen.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Halmoy, S. Johansson, I. Winge, J. A. McKinney, P. M. Knappskog, J. Haavik. Attention-Deficit/Hyperactivity Disorder Symptoms in Offspring of Mothers With Impaired Serotonin Production. Archives of General Psychiatry, 2010; 67 (10): 1033 DOI: 10.1001/archgenpsychiatry.2010.124

Cite This Page:

JAMA and Archives Journals. "ADHD more common in offspring of mothers with genetic serotonin deficiencies." ScienceDaily. ScienceDaily, 5 October 2010. <www.sciencedaily.com/releases/2010/10/101004162940.htm>.
JAMA and Archives Journals. (2010, October 5). ADHD more common in offspring of mothers with genetic serotonin deficiencies. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/10/101004162940.htm
JAMA and Archives Journals. "ADHD more common in offspring of mothers with genetic serotonin deficiencies." ScienceDaily. www.sciencedaily.com/releases/2010/10/101004162940.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins