Featured Research

from universities, journals, and other organizations

Researchers create experimental vaccine against Alzheimer's

Date:
October 8, 2010
Source:
UT Southwestern Medical Center
Summary:
Researchers have created an experimental vaccine against beta-amyloid, the small protein that forms plaques in the brain and is believed to contribute to the development of Alzheimer's disease.

Researchers at UT Southwestern Medical Center have created an experimental vaccine against beta-amyloid, the small protein that forms plaques in the brain and is believed to contribute to the development of Alzheimer's disease.

Related Articles


Compared with similar so-called DNA vaccines that the UT Southwestern researchers tested in an animal study, the new experimental vaccine stimulated more than 10 times as many antibodies that bind to and eliminate beta-amyloid. The results appeared in the journal Vaccine.

Future studies will focus on determining the safety of the vaccine and whether it protects mental function in animals, said Dr. Roger Rosenberg, director of the Alzheimer's Disease Center at UT Southwestern and senior author of the study.

"The antibody is specific; it binds to plaque in the brain. It doesn't bind to brain tissue that does not contain plaque," Dr. Rosenberg said. "This approach shows promise in generating enough antibodies to be useful clinically in treating patients."

A traditional vaccine -- an injection of beta-amyloid protein itself into the arm -- has been shown in other research to trigger an immune response, including the production of antibodies and other bodily defenses against beta-amyloid. However, the immune response to this type of vaccine sometimes caused significant brain swelling, so Dr. Rosenberg and his colleagues focused on developing a nontraditional DNA vaccine.

The DNA vaccine does not contain beta-amyloid itself but instead a piece of the beta-amyloid gene that codes for the protein. In the current study, the researchers coated tiny gold beads with the beta-amyloid DNA and injected them into the skin of the animals' ears. Once in the body, the DNA stimulated an immune response, including antibodies to beta-amyloid.

The next step in the research is to test long-term safety in animals, Dr. Rosenberg said.

"After seven years developing this vaccine, we are hopeful it will not show any significant toxicity, and that we will be able to develop it for human use," he said.

Other UT Southwestern neurology researchers involved in the study were Dr. Bao-Xi Qu, assistant professor; Dr. Doris Lambracht-Washington, research scientist; Min Fu, research associate; Dr. Todd Eagar, assistant professor; and Dr. Olaf Stόve, associate professor.

The study was funded by the National Institutes of Health, The Rudman Foundation and the Alzheimer's Association.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bao-Xi Qu, Doris Lambracht-Washington, Min Fu, Todd N. Eagar, Olaf Stόve, Roger N. Rosenberg. Analysis of three plasmid systems for use in DNA Aβ42 immunization as therapy for Alzheimer's disease. Vaccine, 2010; 28 (32): 5280 DOI: 10.1016/j.vaccine.2010.05.054

Cite This Page:

UT Southwestern Medical Center. "Researchers create experimental vaccine against Alzheimer's." ScienceDaily. ScienceDaily, 8 October 2010. <www.sciencedaily.com/releases/2010/10/101008171843.htm>.
UT Southwestern Medical Center. (2010, October 8). Researchers create experimental vaccine against Alzheimer's. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/10/101008171843.htm
UT Southwestern Medical Center. "Researchers create experimental vaccine against Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2010/10/101008171843.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins