Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain.
This is shown in a new study done by researchers at the Hertie Institute of Clinical Brain Research (HIH, University Hospital Tübingen, University of Tübingen) and the German Center for Neurodegenerative Diseases (DZNE), published in Science.
Alzheimer's disease and a brain vascular disorder called cerebral beta-amyloid angiopathy are characterized by the accumulation of a protein fragment known as Aβ. In Alzheimer´s disease, misfolded Aβ is deposited mainly in so-called amyloid plaques, whereas in cerebral beta-amyloid angiopathy, the Aβ protein aggregates in the walls of blood vessels, interfering with their function and, in some cases, causing them to rupture with subsequent intracerebral bleeding.
In 2006, scientists in Tübingen, led by Mathias Jucker, reported that injection of dilute extracts from Alzheimer's disease brain tissue, or from Aβ-laden mouse brain tissue, into the brains of transgenic mice (genetically modified to produce the human form of Aβ) stimulated Aβ aggregation within the mouse brain (Science 313: 1781-4, 2006).
In the current Science study, Professor Jucker and first author Yvonne Eisele, together with their research team (HIH, University of Tübingen, DZNE) and colleagues Matthias Staufenbiel (Novartis), Mathias Heikenwälder (University of Zürich), and Lary Walker (Emory University, Atlanta) report that Aβ deposition can be induced in the transgenic mouse brain by the intraperitoneal administration of mouse brain extract containing misfolded Aβ. This induced Aβ deposition was primarily associated with the vasculature, but was also evident as amyloid plaques between nerve cells. The time needed to induce amyloid deposition in the brain was much longer for peripheral as compared to direct brain administration. In both cases, the induced amyloid deposition also triggered several neurodegenerative and neuroinflammatory changes commonly observed in the brains of patients with Alzheimer´s disease and cerebral beta-amyloid angiopathy.
"The finding that mechanisms exist allowing for the transport of Aβ aggregates from the periphery to the brain raises the question of whether protein aggregation and propagation, which may also be involved in other neurodegenerative brain diseases, can be induced by agents originating in the periphery," points out Professor Jucker. The present findings provide new clues on pathogenetic mechanisms underlying Alzheimer's disease; further investigation will likely lead to new strategies for prevention and treatment.
While this molecular principle of induced protein aggregation bears similarities to that of prion diseases, the latter, which include bovine spongiform encephalopathy (BSE), can also be initiated by introducing prions at sites peripheral to the brain. The present study shows that this is not a characteristic unique to prion diseases, as has been assumed so far. Despite this remarkable observation and the apparent mechanistic similarities between Alzheimer´s and prion diseases, there is no evidence that Alzheimer's disease or cerebral amyloid angiopathy is transmitted between mammals or humans in the same manner as prion diseases.
- Y. S. Eisele, U. Obermuller, G. Heilbronner, F. Baumann, S. A. Kaeser, H. Wolburg, L. C. Walker, M. Staufenbiel, M. Heikenwalder, M. Jucker. Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis. Science, 2010; DOI: 10.1126/science.1194516
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