Featured Research

from universities, journals, and other organizations

Studies assess complications and deaths from 2009 H1N1 influenza among children

Date:
November 1, 2010
Source:
JAMA and Archives Journals
Summary:
More than one-fourth of children hospitalized with 2009 novel influenza A (H1N1) in California required intensive care or died, according to a new report. Another report assessing children in Israel found that those with underlying illnesses and infants born prematurely were at greater risk of severe complications following 2009 novel influenza A (H1N1) infection.

More than one-fourth of children hospitalized with 2009 novel influenza A(H1N1) in California required intensive care or died, according to a report in the November issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals. A second report assessing children in Israel found that those with underlying illnesses and infants born prematurely were at greater risk of severe complications following 2009 novel influenza A(H1N1) infection.

Related Articles


"Following the detection of the first cases of 2009 novel influenza A(H1N1) in California in April 2009, the virus has rapidly spread throughout the world," the authors write as background information in one of the articles. "In the United States, observations suggest that most cases of 2009 novel influenza A(H1N1) are in children or young adults, with 40 percent of cases in children between the ages of 10 and 18 years; the attack rate in children aged 5 to 14 years (147 per 100,000) has been higher than that of adults 60 years and older (10.5 per 100,000)."

Janice K. Louie, M.D., M.P.H., and colleagues at the California Department of Public Health, Richmond, analyzed data from standardized report forms and medical records describing 345 children who were known to be hospitalized or died of laboratory-confirmed novel influenza A(H1N1) between April 23 and Aug. 11, 2009.

The median (midpoint) age of these children was 6. The rate of hospitalization was 3.5 per 100,000 children over the 110-day period, with the highest rates in infants younger than 6 months (13.9 per 100,000).

Two-thirds (230 or 67 percent) of those who died or were hospitalized had co-occurring illnesses. More than half (59 percent) had pneumonia, 94 (27 percent) required intensive care and nine (3 percent) died. In addition, more than two-thirds of the children (221 of 319, or 69 percent) received antiviral treatment, including 88 of 202 (44 percent) who were treated within 48 hours of developing symptoms.

The most common symptoms included fever, cough, shortness of breath or difficulty breathing, nausea or vomiting, diarrhea and muscle aches. Central nervous system manifestations were observed in 30 children (8.7 percent) and included seizures (17 children), altered mental status (18 children) or both (12 children).

Factors associated with an increased risk of death or admission to the intensive care unit included congenital heart disease and cerebral palsy or developmental delay; Hispanic children were less likely than white children to experience either outcome. Of the 261 children who had laboratory testing for novel influenza A(H1N1), 221 tested positive, for a sensitivity rate of 85 percent.

"Clinicians should be aware of when and what type of influenza and other respiratory viruses, including 2009 novel influenza A(H1N1), are circulating in their community," the authors conclude. "When 2009 novel influenza A(H1N1) activity is present, clinicians should maintain high suspicion for infection in pediatric patients presenting with febrile respiratory illness and initiate prompt treatment in infants and children with underlying risk factors regardless of rapid antigen test results."

In a second report, Michal Stein, M.D., of Edith Wolfson Medical Center, Holon, Israel, and colleagues assessed data from children hospitalized with 2009 influenza A(H1N1) at seven medical centers in Israel between July 12, 2009, and Dec. 24, 2009. "The most frequent clinical presentations were pneumonia, influenza-like illness, wheezing exacerbation and convulsions," the authors write.

Of the 478 patients studied, the average age was 6.1 years. About 9 percent (42 patients) were admitted to the pediatric intensive care unit and 0.6 percent (three patients) died. Underlying illnesses that predisposed children to complications were detected in 48.7 percent of patients.

"In conclusion, our study showed that the severity and mortality of 2009 influenza A(H1N1) in Israel were milder than those described in earlier publications and were similar to the figures reported in the literature on seasonal influenza," the authors write. "Children with underlying metabolic and neurologic disorders represent the group at highest risk for severe complications following 2009 influenza A(H1N1) infection. Our results also suggest that children with cyanotic heart lesions and infants born prematurely are two additional populations at significant risk for a complicated hospital course following infection with 2009 influenza A(H1N1) virus."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. J. K. Louie, S. Gavali, M. Acosta, M. C. Samuel, K. Winter, C. Jean, C. A. Glaser, B. T. Matyas, R. Schechter. Children Hospitalized With 2009 Novel Influenza A(H1N1) in California. Archives of Pediatrics and Adolescent Medicine, 2010; 164 (11): 1023 DOI: 10.1001/archpediatrics.2010.203
  2. M. Stein, D. Tasher, D. Glikman, Y. Shachor-Meyouhas, G. Barkai, A. B. Yochai, E. Leibovitz, M. Hausman-Kedem, A. Hess, O. Megged, I. Kassis, G. Gresario, E. Somekh. Hospitalization of Children With Influenza A(H1N1) Virus in Israel During the 2009 Outbreak in Israel: A Multicenter Survey. Archives of Pediatrics and Adolescent Medicine, 2010; 164 (11): 1015 DOI: 10.1001/archpediatrics.2010.195

Cite This Page:

JAMA and Archives Journals. "Studies assess complications and deaths from 2009 H1N1 influenza among children." ScienceDaily. ScienceDaily, 1 November 2010. <www.sciencedaily.com/releases/2010/11/101101161833.htm>.
JAMA and Archives Journals. (2010, November 1). Studies assess complications and deaths from 2009 H1N1 influenza among children. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2010/11/101101161833.htm
JAMA and Archives Journals. "Studies assess complications and deaths from 2009 H1N1 influenza among children." ScienceDaily. www.sciencedaily.com/releases/2010/11/101101161833.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com
In Rural Sierra Leone the Red Cross Battles Ebola

In Rural Sierra Leone the Red Cross Battles Ebola

AFP (Dec. 17, 2014) The Red Cross battles the Ebola virus in rural Sierra Leone and its fallout. In one treatment centre in the city of Kenema, the Red Cross also runs a kindergarten. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins