Featured Research

from universities, journals, and other organizations

Gefitinib may have chemopreventive benefits in pancreatic cancer

Date:
November 8, 2010
Source:
American Association for Cancer Research
Summary:
Gefitinib may be a promising chemoprevention agent for pancreatic cancer, according to new study.

Gefitinib may be a promising chemoprevention agent for pancreatic cancer, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Related Articles


The study is published in the November issue, and was discussed during a press conference at the Ninth Annual Frontiers in Cancer Prevention Research Conference, held here Nov. 7-10, 2010.

Pancreatic cancer has a dismal prognosis because it is often asymptomatic and not detected until it is in late stages. Strategies to combat pancreatic cancer have focused on earlier and earlier treatments, and this is the first time that a chemoprevention strategy has been tried.

Chinthalapally V. Rao, Ph.D., director of the Center for Chemoprevention and Cancer Drug Development at the University of Oklahoma Cancer Institute, tested the strategy in mice.

The mice were bred to be at high risk for pancreatic cancer and then fed gefitinib in escalating doses of 0, 100 and 200 ppm for a period of 35 weeks, at which time the tumor incidence was analyzed.

Compared to the group that received no gefitinib, the mid-dose group experienced 77 percent fewer pancreatic tumors and the high-dose group had 100 percent fewer tumors.

In the 100 ppm group, 67.6 percent of the mice were free of pancreatic intraepithelial neoplasms, a known pre-cursor to pancreatic cancer, compared with 77.3 percent in the 200 ppm group.

"These findings are dramatic enough that human trials should begin soon," said Rao. "The clear message is that the earlier we start, the better the outcome is, and we can already measure neoplasm levels in humans so there is a potential here for clinical benefit."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Mohammed, N. B. Janakiram, Q. Li, V. Madka, M. Ely, S. Lightfoot, H. Crawford, V. E. Steele, C. V. Rao. The Epidermal Growth Factor Receptor Inhibitor Gefitinib Prevents the Progression of Pancreatic Lesions to Carcinoma in a Conditional LSL-KrasG12D/+ Transgenic Mouse Model. Cancer Prevention Research, 2010; 3 (11): 1417 DOI: 10.1158/1940-6207.CAPR-10-0038

Cite This Page:

American Association for Cancer Research. "Gefitinib may have chemopreventive benefits in pancreatic cancer." ScienceDaily. ScienceDaily, 8 November 2010. <www.sciencedaily.com/releases/2010/11/101108140408.htm>.
American Association for Cancer Research. (2010, November 8). Gefitinib may have chemopreventive benefits in pancreatic cancer. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2010/11/101108140408.htm
American Association for Cancer Research. "Gefitinib may have chemopreventive benefits in pancreatic cancer." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108140408.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins