Featured Research

from universities, journals, and other organizations

Chemoprevention biomarker for breast cancer identified

Date:
November 10, 2010
Source:
American Association for Cancer Research
Summary:
Researchers have identified a possible biomarker for measuring progress in breast cancer chemoprevention trials, according to new research.

Researchers at Duke University Medical Center have identified a possible biomarker for measuring progress in breast cancer chemoprevention trials, according to data presented at the Ninth Annual AACR Frontiers in Cancer Prevention Research Conference, held Nov. 7-10 in Philadelphia.

Although breast cancer treatments are constantly being tested, the progress in chemoprevention has been slower because of a lack of reasonable outcomes that can be measured, according to lead researcher Victoria Seewaldt, M.D., director of the prevention program at the Duke University Comprehensive Cancer Center.

"No one expects to get cancer, so we can't measure the rate of people who do not get cancer as a measure of success," said Seewaldt. "The trials would need to be at least 20,000 patients. By identifying this biomarker, we can set up trials that would need only 200 patients."

Seewaldt and colleagues tested for protein network signaling in breast cells from women at high risk for breast cancer. This analysis identified three signaling pathways that would indicate increased risk of breast cancer: Akt/mTOR/PI3K/cSrc, EGFR/MEK/ERK and HER2/bcl-2. Drugs that could lower the rate of these molecular signals could, therefore, prevent increased risk of breast cancer.

"One of the great struggles of chemoprevention is that we cannot crack what happens inside the breast," said Seewaldt. "Using protein signaling, we will be able to figure out which pathways are active before and after a chemoprevention agent."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Chemoprevention biomarker for breast cancer identified." ScienceDaily. ScienceDaily, 10 November 2010. <www.sciencedaily.com/releases/2010/11/101108140410.htm>.
American Association for Cancer Research. (2010, November 10). Chemoprevention biomarker for breast cancer identified. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/11/101108140410.htm
American Association for Cancer Research. "Chemoprevention biomarker for breast cancer identified." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108140410.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Obama: Ebola Outbreak Threat to Global Security

Obama: Ebola Outbreak Threat to Global Security

AP (Sep. 16, 2014) President Obama is ordering U.S. military personnel to West Africa to deal with the Ebola outbreak, which is he calls a potential threat to global security. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins