Featured Research

from universities, journals, and other organizations

Statins fail to reduce colorectal cancer in postmenopausal women, study finds

Date:
November 8, 2010
Source:
American Association for Cancer Research
Summary:
The use of statins among a group of postmenopausal women did not reduce the risk for colorectal cancer, according to the results of a prospective analysis of data from the large population-based Women's Health Initiative.

The use of statins among a group of postmenopausal women did not reduce the risk for colorectal cancer, according to the results of a prospective analysis of data from the large population-based Women's Health Initiative (WHI).

Related Articles


"The results of our study are consistent with the majority of the literature suggesting no significant reduction in colorectal cancer risk among users of statins," said Michael S. Simon, M.D., professor of oncology in the department of oncology at Wayne State University and Barbara Ann Karmanos Cancer Institute, Detroit.

Simon presented these study results at the Ninth Annual AACR Frontiers in Cancer Prevention Research Conference, held Nov. 7-10 in Philadelphia.

According to Simon, the results from several case-control studies have shown a moderate reduction in colorectal cancer risk in people who use statins. However, a majority of the literature researching the association, including data from randomized controlled trials and cohort studies, show no association between statin use and reduced colorectal cancer risk.

"Colorectal cancer is the third leading cause of cancer incidence and death in the United States," he said. "While regular screening has been shown to be effective in decreasing mortality, the majority of the population receives no screening, or inadequate screening, which supports the need to focus on chemoprevention to lower death rates."

One method of colorectal cancer chemoprevention being researched is the use of statins. In this study, Simon and colleagues used data from the WHI to determine if there was a link between colorectal cancer prevention and statins. The study included 159,219 postmenopausal women aged 50 to 79 years. There were 2,000 cases of colorectal cancer identified during an average of 10 years of follow-up.

Women participating in the study were asked to bring all medications to their screening interviews and the use of any statin, or other lipid-lowering medication, was entered into the WHI database. About 8 percent of women in the study were using statins.

The yearly rate of colorectal cancer did not differ between women taking statins and those not taking statins. There was also no difference in risk for colorectal cancer based on the duration of statin use, type of statin, statin potency or use of other lipid-lowering medications. In addition, the researchers identified no link between statin use and tumor location, stage, grade or histology.

According to Simon though, the effect of statins on colorectal cancer risk deserves some additional study in certain patient populations.

"A recent study suggested a possible greater effect of statins in reducing both cardiovascular and colorectal cancer risk among individuals with a genetic variation of the enzyme inhibited by statins," he said. "This finding suggests that future studies should focus on individuals at high risk based on family history or genetic predisposition."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Statins fail to reduce colorectal cancer in postmenopausal women, study finds." ScienceDaily. ScienceDaily, 8 November 2010. <www.sciencedaily.com/releases/2010/11/101108140414.htm>.
American Association for Cancer Research. (2010, November 8). Statins fail to reduce colorectal cancer in postmenopausal women, study finds. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/11/101108140414.htm
American Association for Cancer Research. "Statins fail to reduce colorectal cancer in postmenopausal women, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/11/101108140414.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins