Featured Research

from universities, journals, and other organizations

Boosting supply of key brain chemical reduces fatigue in mice

Date:
December 21, 2010
Source:
Vanderbilt University Medical Center
Summary:
Researchers have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine, the neurotransmitter essential for muscle contraction. The finding could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals fail to reach the muscle.

Researchers at Vanderbilt University have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine, the neurotransmitter essential for muscle contraction.

The finding, reported this month in the journal Neuroscience, could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals fail to reach the muscles, said Randy Blakely, Ph.D., director of the Vanderbilt Center for Molecular Neuroscience.

Blakely and his colleagues inserted a gene into mice that increased the production of a protein called the choline transporter at the neuromuscular junction.

The choline transporter is vital to the capacity for muscle contraction -- including the ability to breathe -- because it regulates the supply of choline, the precursor to acetylcholine. "We reasoned that giving more of this protein might enhance muscle function and reduce nerve-dependent fatigue," Blakely said.

Other researchers have manipulated the gene for the muscle tissue growth factor myostatin to produce animals with greater strength and endurance, but Blakely said this may be the first time "neural endurance" was enhanced by manipulating the nerves that innervate muscle.

Drugs that increase choline transporter activity "could represent a novel therapeutic strategy" for myasthenia gravis and a wide range of other disorders that involve cholinergic signaling deficits, Blakely said.

These disorders include muscular dystrophy, congestive heart failure, depression, schizophrenia, Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD). "The brain uses acetylcholine for a wide variety of functions, including the ability to sustain attention," Blakely noted.

Last year, Blakely and his colleagues reported that a variation in the choline transporter gene is associated with the "combined" type of ADHD, which is characterized by both inattention and hyperactivity/impulsivity.

With funding from the National Institutes of Health (NIH), the researchers are developing choline transporter-targeted agents that could lead to new medications for these conditions.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Lund, A.M. Ruggiero, S.M. Ferguson, J. Wright, B.A. English, P.A. Reisz, S.M. Whitaker, A.C. Peltier, R.D. Blakely. Motor neuron-specific overexpression of the presynaptic choline transporter: impact on motor endurance and evoked muscle activity. Neuroscience, 2010; 171 (4): 1041 DOI: 10.1016/j.neuroscience.2010.09.057

Cite This Page:

Vanderbilt University Medical Center. "Boosting supply of key brain chemical reduces fatigue in mice." ScienceDaily. ScienceDaily, 21 December 2010. <www.sciencedaily.com/releases/2010/12/101220163250.htm>.
Vanderbilt University Medical Center. (2010, December 21). Boosting supply of key brain chemical reduces fatigue in mice. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/12/101220163250.htm
Vanderbilt University Medical Center. "Boosting supply of key brain chemical reduces fatigue in mice." ScienceDaily. www.sciencedaily.com/releases/2010/12/101220163250.htm (accessed July 30, 2014).

Share This




More Mind & Brain News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins