Featured Research

from universities, journals, and other organizations

'Un-growth hormone' increases longevity, researchers find

Date:
December 23, 2010
Source:
Saint Louis University
Summary:
A compound which acts in the opposite way as growth hormone can reverse some of the signs of aging, a research team has shown. The finding may be counter-intuitive to some older adults who take growth hormone, thinking it will help revitalize them.

Youthful senior couple. A compound which acts in the opposite way as growth hormone can reverse some of the signs of aging, a research team has shown. The finding may be counter-intuitive to some older adults who take growth hormone, thinking it will help revitalize them.
Credit: iStockphoto/Catherine Yeulet

A compound which acts in the opposite way as growth hormone can reverse some of the signs of aging, a research team that includes a Saint Louis University physician has shown. The finding may be counter-intuitive to some older adults who take growth hormone, thinking it will help revitalize them.

Their research was published in the Dec. 6 online edition of the Proceedings of the National Academy of Sciences.

The findings are significant, says John E. Morley, M.D., study co-investigator and director of the divisions of geriatric medicine and endocrinology at Saint Louis University School of Medicine, because people sometimes take growth hormone, believing it will be the fountain of youth.

"Many older people have been taking growth hormone to rejuvenate themselves," Morley said. "These results strongly suggest that growth hormone, when given to middle aged and older people, may be hazardous."

The scientists studied the compound MZ-5-156, a "growth hormone-releasing hormone (GHRH) antagonist." They conducted their research in the SAMP8 mouse model, a strain engineered for studies of the aging process. Overall, the researchers found that MZ-5-156 had positive effects on oxidative stress in the brain, improving cognition, telomerase activity (the actions of an enzyme which protects DNA material) and life span, while decreasing tumor activity.

MZ-5-156, like many GHRH antagonists, inhibited several human cancers, including prostate, breast, brain and lung cancers. It also had positive effects on learning, and is linked to improvements in short-term memory. The antioxidant actions led to less oxidative stress, reversing cognitive impairment in the aging mouse.

William A. Banks, M.D., lead study author and professor of internal medicine and geriatrics at the University of Washington School of Medicine in Seattle, said the results lead the team "to determine that antagonists of growth hormone-releasing hormone have beneficial effects on aging."

The study team included as its corresponding author Andrew V. Schally, M.D., Ph.D., a professor in the department of pathology and division of hematology/oncology at the University of Miami Miller School of Medicine.


Story Source:

The above story is based on materials provided by Saint Louis University. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. A. Banks, J. E. Morley, S. A. Farr, T. O. Price, N. Ercal, I. Vidaurre, A. V. Schally. Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice. Proceedings of the National Academy of Sciences, 2010; 107 (51): 22272 DOI: 10.1073/pnas.1016369107

Cite This Page:

Saint Louis University. "'Un-growth hormone' increases longevity, researchers find." ScienceDaily. ScienceDaily, 23 December 2010. <www.sciencedaily.com/releases/2010/12/101223091746.htm>.
Saint Louis University. (2010, December 23). 'Un-growth hormone' increases longevity, researchers find. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/12/101223091746.htm
Saint Louis University. "'Un-growth hormone' increases longevity, researchers find." ScienceDaily. www.sciencedaily.com/releases/2010/12/101223091746.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins