Scientists are reporting an "important step" toward development of a universal blood product that would eliminate the need to "type" blood to match donor and recipient before transfusions. A report on the "immunocamouflage" technique, which hides blood cells from antibodies that could trigger a potentially fatal immune reaction that occurs when blood types do not match, appears in the ACS journal, Biomacromolecules.
Maryam Tabrizian and colleagues note that blood transfusions require a correct match between a donor and the recipient's blood. This can be a tricky proposition given that there are 29 different red blood cells types, including the familiar ABO and Rh types. The wrong blood type can provoke serious immune reactions that result in organ failure or death, so scientists have long sought a way to create an all-purpose red blood cell for transfusions that doesn't rely on costly blood typing or donations of a specific blood type.
To develop this "universal" red blood cell, the scientists discovered a way to encase living, individual red blood cells within a multilayered polymer shell. The shell serves as a cloaking device, they found, making the cell invisible to a person's immune system and able to evade detection and rejection. Oxygen can still penetrate the polymer shell, however, so the red blood cells can carry on their main business of supplying oxygen to the body. "The results of this study mark an important step toward the production of universal RBCs," the study states.
The authors acknowledge funding from the Fonds de la Recherche en Santι du Quιbec, the Natural Sciences and Engineering Council of Canada, the Canadian Institutes for Health Research and FQRNT-Centre for Biorecognition and Biosensors.
- Sania Mansouri, Yahye Merhi, Françoise M. Winnik, Maryam Tabrizian. Investigation of Layer-by-Layer Assembly of Polyelectrolytes on Fully Functional Human Red Blood Cells in Suspension for Attenuated Immune Response. Biomacromolecules, 2011; 110209145123077 DOI: 10.1021/bm101200c
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