Featured Research

from universities, journals, and other organizations

New biomarker may help with early diagnosis of Alzheimer's disease

Date:
June 23, 2011
Source:
American Academy of Neurology
Summary:
A new biomarker may help identify which people with mild memory deficits will go on to develop Alzheimer's disease, according to a new study. The biomarker may be more accurate than the currently established biomarkers.

A new biomarker may help identify which people with mild memory deficits will go on to develop Alzheimer's disease, according to a new study published in the June 22, 2011, online issue of Neurology, the medical journal of the American Academy of Neurology. The biomarker may be more accurate than the currently established biomarkers.

Related Articles


"Being able to identify who will develop Alzheimer's disease very early in the process will be crucial in the future," said study author Robert Perneczky, MD, of the Technical University Munich in Germany. "Once we have treatments that could prevent Alzheimer's disease, we could begin to treat very early and hopefully prevent the loss of memory and thinking skills that occurs with this devastating disease."

The study involved 58 people with slight memory problems, or mild cognitive impairment (MCI). Up to 15 percent of people with mild cognitive impairment develop Alzheimer's disease each year.

A sample of cerebrospinal fluid of the participants was taken at the beginning of the study through a lumbar puncture, or spinal tap. The concentrations in the cerebrospinal fluid of several proteins that are associated with Alzheimer's disease were measured.

The participants were followed for nearly three years on average. At that point, 21 people had developed Alzheimer's disease, 27 still had mild cognitive impairment and eight people had reverted back to their normal cognitive health. Two people had developed frontotemporal dementia, and their results were not included in the analysis.

Researchers found that the people who developed Alzheimer's disease had significantly higher levels of a protein called soluble amyloid precursor protein beta (sAPPβ) in their spinal fluid than those who did not develop Alzheimer's disease. Those who developed Alzheimer's disease had an average of 1,200 nanograms per milliliter, compared to 932 for those who did not develop the disease.

The researchers found that the best predictor of whether someone would develop Alzheimer's disease was a combination of sAPPβ, the tau protein (an established marker of brain cell damage) and the age of the individual. When these factors were combined, the results were roughly 80 percent accurate in predicting whether the disease would develop.

The protein amyloid beta1-42, or Aβ1-42, which has previously been considered a biomarker for Alzheimer's disease, was not a predictive factor in this study.

"These results suggest that sAPPβ as a biomarker may be useful and superior to the established marker Aβ1-42 in the early diagnosis of Alzheimer's disease," Perneczky said.

"One possible explanation is that Aβ1-42 measures events further downstream from the initial steps that lead to the production of the amyloid plaques that accumulate in the brains of people with Alzheimer's disease. sAPPβ is a measure of the first critical step in that process and may therefore provide more accurate information on the core pathological events."

The study was supported by the League of Friends of the Technical University Munich and the Commission for Clinical Research of the Rechts der Isar Munich Hospital.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "New biomarker may help with early diagnosis of Alzheimer's disease." ScienceDaily. ScienceDaily, 23 June 2011. <www.sciencedaily.com/releases/2011/06/110622162306.htm>.
American Academy of Neurology. (2011, June 23). New biomarker may help with early diagnosis of Alzheimer's disease. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2011/06/110622162306.htm
American Academy of Neurology. "New biomarker may help with early diagnosis of Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/06/110622162306.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
Amazing Technology Allows Blind Mother to See Her Newborn Son

Amazing Technology Allows Blind Mother to See Her Newborn Son

RightThisMinute (Jan. 23, 2015) Not only is Kathy seeing her newborn son for the first time, but this is actually the first time she has ever seen a baby. Kathy and her sister, Yvonne, have been legally blind since childhood, but thanks to an amazing new technology, eSight glasses, which gives those who are legally blind the ability to see, she got the chance to see the birth of her son. It&apos;s an incredible moment and an even better story. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins