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Study identifies chemical changes in brains of people at risk for Alzheimer's disease

Date:
August 25, 2011
Source:
American Academy of Neurology
Summary:
A brain imaging scan identifies biochemical changes in the brains of normal people who might be at risk for Alzheimer's disease, according to new research.

A brain imaging scan identifies biochemical changes in the brains of normal people who might be at risk for Alzheimer's disease, according to research published in the Aug. 24, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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The study of 311 people in their 70s and 80s with no cognitive problems, from the population-based Mayo Clinic Study of Aging, used an advanced brain imaging technique called proton MR spectroscopy to see if they had abnormalities in several brain metabolites that may be biomarkers for Alzheimer's disease. They also had PET scans to assess the level of amyloid-beta deposits, or plaques, in the brain that are one of the first signs of changes in the brain due to Alzheimer's disease. The participants were also given tests of memory, language and other skills.

"There is increasing evidence that Alzheimer disease is associated with changes in the brain that start many years before symptoms develop," said Jonathan M. Schott, MD, of the Dementia Research Centre, University College London in England and a member of the American Academy of Neurology, who wrote an editorial accompanying the study. "If we could identify people in whom the disease process has started but symptoms have not yet developed, we would have a potential window of opportunity for new treatments -- as and when they become available -- to prevent or delay the start of memory loss and cognitive decline."

The study found that 33 percent of the participants had significantly high levels of amyloid-beta deposits in their brains. Those with high levels of amyloid-beta deposits also tended to have high levels of the brain metabolites myoinositol/creatine and choline/creatine. People with high levels of choline/creatine were more likely to have lower scores on several of the cognitive tests, regardless of the amount of amyloid-beta deposits in their brains.

"This relationship between amyloid-beta deposits and these metabolic changes in the brain are evidence that some of these people may be in the earliest stages of the disease," said study author Kejal Kantarci, MD, MSc, of the Mayo Clinic in Rochester, Minn., and a member of the American Academy of Neurology. "More research is needed that follows people over a period of years to determine which of these individuals will actually develop the disease and what the relationship is between the amyloid deposits and the metabolites." At the present time, MR spectroscopy cannot be used for diagnosis.

The study was supported by the Paul Beeson Award in Aging, National Institutes of Health and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Journal References:

  1. K. Kantarci, V. Lowe, S. A. Przybelski, M. L. Senjem, S. D. Weigand, R. J. Ivnik, R. Roberts, Y. E. Geda, B. F. Boeve, D. S. Knopman, R. C. Petersen, C. R. Jack, Jr. Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology, 2011; DOI: 10.1212/WNL.0b013e31822dc7e1
  2. Jonathan M. Schott. Spectra to identify the spectre of Alzheimer disease? Neurology, 2011; DOI: 10.1212/WNL.0b013e31822cfce6

Cite This Page:

American Academy of Neurology. "Study identifies chemical changes in brains of people at risk for Alzheimer's disease." ScienceDaily. ScienceDaily, 25 August 2011. <www.sciencedaily.com/releases/2011/08/110824192343.htm>.
American Academy of Neurology. (2011, August 25). Study identifies chemical changes in brains of people at risk for Alzheimer's disease. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2011/08/110824192343.htm
American Academy of Neurology. "Study identifies chemical changes in brains of people at risk for Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2011/08/110824192343.htm (accessed October 31, 2014).

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