Featured Research

from universities, journals, and other organizations

Gender, insurance type tied to HPV infection in laryngeal cancer patients

Date:
September 14, 2011
Source:
Henry Ford Health System
Summary:
The human papillomavirus (HPV) is more likely to be found in tumors of laryngeal cancer patients who are male and those with private health insurance, according to a new study from researchers at Henry Ford Hospital. The study also reveals that laryngeal cancer patients with Medicare, who tend to be 65 and older, have a lower prevalence of HPV, suggesting that HPV infection may be closely tied to age and changes in sexual behavior with younger generations.

The human papillomavirus (HPV) is more likely to be found in tumors of laryngeal cancer patients who are male and those with private health insurance, according to a new study from researchers at Henry Ford Hospital.

Related Articles


The study also reveals that laryngeal cancer patients with Medicare, who tend to be 65 and older, have a lower prevalence of HPV, suggesting that HPV infection may be closely tied to age and changes in sexual behavior with younger generations.

"Our study is an important step forward in learning more about HPV trends, and ultimately learning how HPV positive status could impact screening and treatment for laryngeal cancer patients," says study lead author Josena Stephen, M.D., a research scientist investigator in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

"This is relevant because HPV positive patients, particularly those with oropharyngeal cancer, have improved survival. For laryngeal cancer this remains to be established."

Results from the study will be presented Sept. 14 in San Francisco at the American Academy of Otolaryngology-Head & Neck Surgery Foundation Annual Meeting.

In 2010, an estimated 12,700 new cases of laryngeal cancer -- cancers that start in the voice box -- were diagnosed, according to the National Cancer Institute. Like other head and neck cancers, risk factors include smoking, alcohol consumption. HPV is a risk factor in some head and neck cancers, such as oropharyngeal cancer.

Prior HPV-related research for head and neck cancer has been focused on oropharyngeal cancer, which includes the base of the tongue, the tonsils, the soft palate (back of the mouth), and the walls of the pharynx (throat).

In those studies, HPV-positive patients with oropharyngeal cancer were shown to have a reduced risk of death and respond better to treatment. With laryngeal cancer, little is known about HPV prevalence and how HPV might impact survival.

The Henry Ford study takes a closer look at HPV prevalence based on race, gender and insurance type, as well as stage and survival for laryngeal cancer patients.

The study group included information and tissue samples for 79 patients, of which 60 were male and 19 were female. The patients were categorized into two groups: no treatment and treatment (radiation and/or chemotherapy).

Most notably, 41% percent of the study group was African American, and the majority of the study group (95%) had a history of smoking. The study found HPV-positive status for laryngeal cancer to be significantly tied to gender, with 34% of men and 5% of women having HPV.

Insurance type also was associated with HPV status. The majority of private insurance patients were found to have HPV, while the Medicare group had far more HPV-negative patients than HPV-positive patients.

HPV had a lower prevalence in African American patients. It was detected in 16% of African Americans as compared to 33% of Caucasian in the study.

"It's very revealing what's embedded in this study, particularly for African American patients," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

"We know that African Americans are disproportionately diagnosed with late-stage cancer and have worse outcomes than Caucasians. This study really builds on sexual behavioral lifestyle-related evidence that may be contributing to outcomes, especially since there's a significant difference between HPV status in African Americans and Caucasian populations."

The study results also suggest that, similar to oropharyngeal cancer research, laryngeal cancer patients with HPV have better survival and tend to respond better to chemotherapy and radiation treatments than patients who do not have HPV.

The researchers say, however, that this pattern needs to be further studied to confirm such results, and they plan to do so using a larger group of patients.

Along with Drs. Stephen and Worsham, study co-authors from Henry Ford are Kang Mei Chen, M.D.; Veena Shah, M.D.; Shaleta Havard; Mei Lu, Ph.D.; Vanessa G. Schweitzer, M.D.; and Glendon Gardner, M.D.

The research was funded by a NIH grant.


Story Source:

The above story is based on materials provided by Henry Ford Health System. Note: Materials may be edited for content and length.


Cite This Page:

Henry Ford Health System. "Gender, insurance type tied to HPV infection in laryngeal cancer patients." ScienceDaily. ScienceDaily, 14 September 2011. <www.sciencedaily.com/releases/2011/09/110914131344.htm>.
Henry Ford Health System. (2011, September 14). Gender, insurance type tied to HPV infection in laryngeal cancer patients. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/09/110914131344.htm
Henry Ford Health System. "Gender, insurance type tied to HPV infection in laryngeal cancer patients." ScienceDaily. www.sciencedaily.com/releases/2011/09/110914131344.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins