Featured Research

from universities, journals, and other organizations

Nanosurgery and the fight against cancer

Date:
February 16, 2012
Source:
Polytechnique Montréal
Summary:
Researchers have succeeded in changing the genetic material of cancer cells using a brand-new transfection method. This breakthrough in nanosurgery opens the door to new medical applications, among others for the treatment of cancers.

Researchers have succeeded in changing the genetic material of cancer cells using a brand-new transfection method.
Credit: Image courtesy of Polytechnique Montréal

Researchers at Polytechnique Montréal have succeeded in changing the genetic material of cancer cells using a brand-new transfection method. This breakthrough in nanosurgery opens the door to new medical applications, among others for the treatment of cancers.

Related Articles


A light scalpel to treat cancerous cells

The unique method developed by Professor Michel Meunier and his team uses a femtosecond laser (a laser with ultra-short pulses) along with gold nanoparticles. Deposited on the cells, these nanoparticles concentrate the laser's energy and make it possible to perform nanometric-scale surgery in an extremely precise and non-invasive fashion. The technique allows to change the expression of genes in the cancer cells and could be used to slow their migration and prevent the formation of metastases.

The technique perfected by Professor Meunier and his colleagues is a promising alternative to conventional cellular transfection methods, such as lipofection. The experiment, carried out in Montréal laboratories on malignant human melanoma cells, demonstrated 70% optoporation effectiveness, as well as a transfection performance three times higher than lipofection treatment. In addition, unlike conventional treatment, which destroys the physical integrity of the cells, the new method assures cellular viability, with a toxicity of less than 1%.

The study's results were published in the journal Biomaterials.

This scientific breakthrough could lead to the development of promising applications, including new therapeutic approaches in oncology, neurology and cardiology.

Professor Meunier's team works in collaboration with researchers from the Department of Medicine at the McGill University Health Centre. Their research work receives financial support from the Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT), the Canada Foundation for Innovation (CFI), the Canada Research Chairs program (CRC), the Canadian Institutes of Health Research (CIHR) and the Deutsche Forschungsgemeinschaft (DFG).


Story Source:

The above story is based on materials provided by Polytechnique Montréal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Judith Baumgart, Laure Humbert, Étienne Boulais, Rémi Lachaine, Jean-Jaques Lebrun, Michel Meunier. Off-resonance plasmonic enhanced femtosecond laser optoporation and transfection of cancer cells. Biomaterials, 2012; 33 (7): 2345 DOI: 10.1016/j.biomaterials.2011.11.062

Cite This Page:

Polytechnique Montréal. "Nanosurgery and the fight against cancer." ScienceDaily. ScienceDaily, 16 February 2012. <www.sciencedaily.com/releases/2012/02/120216133918.htm>.
Polytechnique Montréal. (2012, February 16). Nanosurgery and the fight against cancer. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2012/02/120216133918.htm
Polytechnique Montréal. "Nanosurgery and the fight against cancer." ScienceDaily. www.sciencedaily.com/releases/2012/02/120216133918.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) — The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) — Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins