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High levels of TRAIL protein in breast milk might contribute to anticancer activity

Date:
April 23, 2012
Source:
SAGE Publications
Summary:
The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study found high levels of cancer-fighting TNF-related apoptosis inducing ligand (TRAIL) in human milk, which might be one source of breast milk's anticancer activity.

The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study in the Journal of Human Lactation (published by SAGE) found high levels of cancer-fighting TNF-related apoptosis inducing ligand (TRAIL) in human milk, which might be one source of breast milk's anticancer activity.

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Researchers took samples of colostrum, the first milk available to newborns, and of mature breast milk from new mothers. Researchers then obtained samples of blood from healthy women, and various ready-to-feed infant formulas. The colostrum, mature breast milk, blood and formula were then all tested to measure their level of TRAIL. The researchers found that colostrum and breast milk contained 400- and 100-fold, respectively, higher levels of TRAIL than blood. No TRAIL was detected in the formula.

"The important role of breastfeeding in the prevention of certain childhood cancers, such as lymphoblastic leukemia, Hodgkin's disease, and neuroblastoma, has been previously demonstrated," wrote the authors. "However, endogenous soluble TRAIL represents a strong candidate to explain the overall biological effect of breastfeeding against cancer."

Mothers chosen to participate in the study were eligible because they exhibited no signs of eclampsia, infection, or fever, and delivered healthy newborns at term.

The authors wrote, "To our knowledge, this is the first time that TRAIL has been measured in colostrum and human breast milk. This study has revealed much higher TRAIL concentrations in colostrum and breast milk compared to the levels of circulating serum TRAIL."


Story Source:

The above story is based on materials provided by SAGE Publications. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Davanzo, G. Zauli, L. Monasta, L. Vecchi Brumatti, M. V. Abate, G. Ventura, E. Rimondi, P. Secchiero, S. Demarini. Human Colostrum and Breast Milk Contain High Levels of TNF-Related Apoptosis-Inducing Ligand (TRAIL). Journal of Human Lactation, 2012; DOI: 10.1177/0890334412441071

Cite This Page:

SAGE Publications. "High levels of TRAIL protein in breast milk might contribute to anticancer activity." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423153145.htm>.
SAGE Publications. (2012, April 23). High levels of TRAIL protein in breast milk might contribute to anticancer activity. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/04/120423153145.htm
SAGE Publications. "High levels of TRAIL protein in breast milk might contribute to anticancer activity." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423153145.htm (accessed October 31, 2014).

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