Featured Research

from universities, journals, and other organizations

Intravenous vaccination promotes brain plasticity and prevents memory loss in Alzheimer's disease

Date:
April 23, 2012
Source:
Federation of American Societies for Experimental Biology (FASEB)
Summary:
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease affecting over five million people worldwide, and is the leading cause of dementia in the elderly. Currently, intravenous human immunoglobulin (IVIG) treatment is being explored in multiple off-label uses other than immunotherapy, including AD. Several clinical studies assessing the tolerability and efficacy of IVIG in Alzheimer's disease subjects are in progress with inconsistent outcomes.

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease affecting over five million people worldwide, and is the leading cause of dementia in the elderly. Currently, intravenous human immunoglobulin (IVIG) treatment is being explored in multiple off-label uses other than immunotherapy, including AD. Several clinical studies assessing the tolerability and efficacy of IVIG in Alzheimer's disease subjects are in progress with inconsistent outcomes.

Related Articles


Recent studies conducted by Dr. Giulio Maria Pasinetti, Saunders Family Chair and Professor in Neurology and Psychiatry at Mount Sinai School of Medicine in New York, suggests that the divergent outcomes in Alzheimer's disease clinical studies of IVIG may be due to differences in temporal administration and administered dosages.

Dr. Pasinetti and his team of investigators recently found that prolonged administration of human immunoglobulin in models of Alzheimer's disease, using a dose of immunoglobulin ~5-20-fold less than equivalent doses used in Alzheimer's disease patients, is effective at attenuating Alzheimer's disease-type cognitive dysfunction while promoting synaptic plasticity. "This experimental observation provides a rational basis for rectifying the inconsistency of study outcomes in Alzheimer's disease clinical trials with IVIG," said Dr. Pasinetti. Recent evidence from Dr. Pasinetti's laboratory and others suggests that a mechanism by which IVIG may benefit cognition is through the increase of brain contents of certain mediators of natural immunity, such as the complement component-derived anaphylatoxins C5a and C3a, capable of promoting synaptic plasticity and neuroprotection.

"We now have the much needed information supporting the potential application of slow release of immunoglobulins delivered subcutaneously to delay the onset of Alzheimer's disease, even at pre-symptomatic stages of the disease" said Dr. Pasinetti.

Dr. Pasinetti hypothesizes that the slow release of immuglobulins into the circulation and eventually into the brain for a protracted period of time may delay Alzheimer's disease dementia onset and eventually its progression through epigenetic changes in the downstream gene expression of C5a-mediated pCREB-C/EBP signaling components associated with modulation of synaptic plasticity and eventually learning and memory functions.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology (FASEB). "Intravenous vaccination promotes brain plasticity and prevents memory loss in Alzheimer's disease." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423162227.htm>.
Federation of American Societies for Experimental Biology (FASEB). (2012, April 23). Intravenous vaccination promotes brain plasticity and prevents memory loss in Alzheimer's disease. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2012/04/120423162227.htm
Federation of American Societies for Experimental Biology (FASEB). "Intravenous vaccination promotes brain plasticity and prevents memory loss in Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423162227.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins