Featured Research

from universities, journals, and other organizations

New animal model for one of the least understood medical issues: ADHD

Date:
May 10, 2012
Source:
Oregon Health & Science University
Summary:
To better understand the cause of ADHD and to identify methods to prevent and treat it, researchers have developed a new form of specially bred mouse that mimics the condition.

The number of attention deficit hyperactivity disorder (ADHD) cases in the United States are exploding. According to a 2011 statement by the Centers for Disease Control and Prevention, nearly one in 10 American children is diagnosed with the disorder. To better understand the cause of ADHD and to identify methods to prevent and treat it, researchers at Oregon Health & Science University (OHSU) and OHSU's Oregon National Primate Research Center have developed a new form of specially bred mouse that mimics the condition.

The research is published in the current edition of the PLoS ONE, a journal of the Public Library of Science.

The research, led by OHSU and ONPRC scientists Jacob Raber, Ph.D., and Sergio Ojeda, D.V.M., found that mice carrying a certain mutated form of gene displayed the human-like symptoms of ADHD. The scientists believe that mice bred with this unique genome can greatly assist in research to combat ADHD.

The specific gene that was studied in this research is called SynCAM1, which is found in glial cells -- a type of cell in the central nervous system involved in cellular communication. The researchers found that mice carrying a dominant/negative form of the gene were hyperactive. The mice displayed enhanced and more frequent activity during rest periods. In addition, the mice exhibited reduced anxiety, similar to children diagnosed with ADHD. The mutated gene caused these conditions because it blocks the actions of the normal gene.

"While some animal models for ADHD exist, they are far from perfect," explained Raber, a professor of behavioral neuroscience and neurology in the OHSU School of Medicine and an affiliate scientist at ONPRC "For instance, a rat model of this condition displays high blood pressure also known as spontaneous hypertensive rats or SHR, which is not observed in humans with ADHD. When hypertension is eliminated by crossing SHR rats to another commonly studied rat breed, the resulting rat has normal blood pressure but no longer responds to the methylphenidate in a way that humans with ADHD do."

"We believe that this animal model may more closely mimic ADHD and shed new light on this condition," added Ojeda, a senior scientist at ONPRC.

The ONPRC, National Institutes of Health and the National Alliance for Research on Schizophrenia and Depression funded this research.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ursula S. Sandau, Zefora Alderman, Gabriel Corfas, Sergio R. Ojeda, Jacob Raber. Astrocyte-Specific Disruption of SynCAM1 Signaling Results in ADHD-Like Behavioral Manifestations. PLoS ONE, 2012; 7 (4): e36424 DOI: 10.1371/journal.pone.0036424

Cite This Page:

Oregon Health & Science University. "New animal model for one of the least understood medical issues: ADHD." ScienceDaily. ScienceDaily, 10 May 2012. <www.sciencedaily.com/releases/2012/05/120510100353.htm>.
Oregon Health & Science University. (2012, May 10). New animal model for one of the least understood medical issues: ADHD. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/05/120510100353.htm
Oregon Health & Science University. "New animal model for one of the least understood medical issues: ADHD." ScienceDaily. www.sciencedaily.com/releases/2012/05/120510100353.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins