Featured Research

from universities, journals, and other organizations

Maternal gluten sensitivity linked to schizophrenia risk in children

Date:
May 11, 2012
Source:
Karolinska Institutet
Summary:
Babies born to women with sensitivity to gluten appear to be at increased risk of developing schizophrenia and other psychiatric disorders later in life, according to new findings from Karolinska Institutet in Sweden and Johns Hopkins University, United States.

Babies born to women with sensitivity to gluten appear to be at increased risk of developing schizophrenia and other psychiatric disorders later in life, according to new findings from Karolinska Institutet in Sweden and Johns Hopkins University, United States.

Related Articles


Maternal infections and other inflammatory disorders during pregnancy have long been linked to a greater risk for schizophrenia in the offspring. However the current study, which will be published in the June issue of the American Journal of Psychiatry, is the first to point to maternal food sensitivity as a possible culprit in the development of such disorders later in life.

"Lifestyle and genes are not the only factors that shape the risk of developing a certain disease, but factors during the pregnancy and immediately after birth can also be involved in the pre-programming of our adult health. However, this does not mean that sensitivity to certain foods invariably will cause schizophrenia, on the contrary ," says Dr Hεkan Karlsson, who led the study together with Dr Christina Dalman, both at Karolinska Institutet.

The team's findings are based on an examination of 764 birth records and neonatal blood samples of Swedes born between 1975 and 1985. 211 of these children subsequently developed non-affective psychoses, such as schizophrenia and delusional disorders. Using stored neonatal blood samples, the investigators measured levels of IgG antibodies -- markers of immune system reaction -- triggered by the presence of the cow's milk protein casein and a protein called gliadin. Gliadin is a component of gluten, which in turn can be found in wheat, barley and rye. Because a mother's antibodies cross the placenta during pregnancy to confer immunity to the baby, a newborn's elevated IgG levels indicate an immune response to proteins in the mother.

The results of the study show that children born to mothers with abnormally high levels of antibodies to gliadin had nearly twice the risk of developing non-affective psychosis later in life, compared with children who had normal levels of gliadin antibodies. The risk for psychosis was not increased among those with elevated levels of antibodies to casein. The link persisted even after researchers accounted for other factors known to increase schizophrenia risk, such as maternal age, gestational age, birth by Caesarean section, and birth weight.

"There are studies in the past that show that people diagnosed with schizophrenia more often than others are suffering from various forms of immune responses to gluten. We will now conduct follow-up studies to clarify how gluten or sensitivity to it increases schizophrenia risk and whether it does so only in those genetically predisposed," says Dr Karlsson.

The research was funded by the Stanley Medical Research Institute, the Swedish Research Council and the Stockholm County Council. Dr Karlsson currently also works at the Johns Hopkins Children's Center in Baltimore.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Εsa Blomstrφm. Maternal Antibodies to Dietary Antigens and Risk for Nonaffective Psychosis in Offspring. American Journal of Psychiatry, 2012; DOI: 10.1176/appi.ajp.2012.11081197

Cite This Page:

Karolinska Institutet. "Maternal gluten sensitivity linked to schizophrenia risk in children." ScienceDaily. ScienceDaily, 11 May 2012. <www.sciencedaily.com/releases/2012/05/120511101242.htm>.
Karolinska Institutet. (2012, May 11). Maternal gluten sensitivity linked to schizophrenia risk in children. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2012/05/120511101242.htm
Karolinska Institutet. "Maternal gluten sensitivity linked to schizophrenia risk in children." ScienceDaily. www.sciencedaily.com/releases/2012/05/120511101242.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins