Featured Research

from universities, journals, and other organizations

The doping-drug Epo has an impact in the brain

Date:
June 11, 2012
Source:
University of Zurich
Summary:
Sportsmen and women have been known to dope with the blood hormone Epo to enhance their performance. Researchers have now discovered, through animal testing, that Epo has a performance-enhancing effect in the brain shortly after an injection by improving oxygen transport in blood. As Epo also increases motivation, it could be useful in treating depression, experts say.

Sportsmen and women have been known to dope with the blood hormone Epo to enhance their performance. Researchers from the University of Zurich have now discovered, through animal testing, that Epo has a performance-enhancing effect in the brain shortly after an injection by improving oxygen transport in blood. As Epo also increases motivation, it could be useful in treating depression, experts say.

The well-known blood hormone Epo is not only used for medicinal purposes; some athletes misuse it for doping. It boosts the number of red blood cells, thereby increasing the transport of oxygen to the muscles. This leads to improvements in performance, which can especially give endurance athletes such as cyclists or marathon runners the edge.

Epo has immediate impact on exercise performance

In a recently published study, Max Gassmann, a veterinary physiologist from the University of Zurich, proved that Epo also drastically increases motivation in the brain as soon as it has been injected, without the number of red blood cells increasing.

Gassmann's team tested exercise performance of differently treated mice, studying genetically modified mice that produce human Epo solely in the brain and mice that the researchers had injected with Epo and the hormone reached the brain thus by blood. Both mouse groups exhibited an increased performance on the treadmill compared to the untreated control animals. "We assume that Epo in the brain triggers a motivation boost to increase physical performance," explains Professor Gassmann. He and his team are now testing the performance-enhancing effect of Epo on volunteers.

Epo probably has an impact on people's moods, too. It might thus be used in patients who suffer from depression. The latest experiments conducted by a German-Danish research group reveal that Epo can also alleviate the condition of patients suffering from schizophrenia by improving their mental performance.


Story Source:

The above story is based on materials provided by University of Zurich. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. Schuler, J. Vogel, B. Grenacher, R. A. Jacobs, M. Arras, M. Gassmann. Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis. The FASEB Journal, 2012; DOI: 10.1096/fj.11-191197

Cite This Page:

University of Zurich. "The doping-drug Epo has an impact in the brain." ScienceDaily. ScienceDaily, 11 June 2012. <www.sciencedaily.com/releases/2012/06/120611105307.htm>.
University of Zurich. (2012, June 11). The doping-drug Epo has an impact in the brain. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/06/120611105307.htm
University of Zurich. "The doping-drug Epo has an impact in the brain." ScienceDaily. www.sciencedaily.com/releases/2012/06/120611105307.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins