Featured Research

from universities, journals, and other organizations

Preclinical studies use specialized ultrasound to detect presence of cancer

Date:
July 10, 2012
Source:
University of North Carolina Health Care
Summary:
Vessel "bendiness" can indicate the presence and progression of cancer. This principle led scientists to a new method of using a high-resolution ultrasound to identify early tumors in preclinical studies. The method, based on vessel bendiness or "tortuosity," potentially offers an inexpensive, non-invasive and fast method to detect cancer that could someday help doctors identify cancers when tumors are less than a centimeter in size.

This is a dual-mode ultrasound image, showing traditional grayscale ultrasound of a subcutaneous tumor, simultaneously with acoustic angiography. The new technique of acoustic angiography enables visualization of the tissue microvasculature (red). Scientists have shown that this type of microvascular imaging can provide insight into the presence of cancer, based on examining the microvasculature alone. Scale bar = 1 cm.
Credit: Image courtesy of the University of North Carolina at Chapel Hill

From the air, the twists and turns of rivers can easily be seen. In the body, however, tracing the twists and turns of blood vessels is difficult, but important. Vessel "bendiness" can indicate the presence and progression of cancer.

This principle led UNC scientists to a new method of using a high-resolution ultrasound to identify early tumors in preclinical studies. The method, based on vessel bendiness or "tortuosity," potentially offers an inexpensive, non-invasive and fast method to detect cancer that could someday help doctors identify cancers when tumors are less than a centimeter in size.

Their findings were published in the July 6, 2012 online issue of the journal Radiology.

Paul Dayton, PhD, associate professor of biomedical engineering explains, "The correlation between vessel tortuosity and cancer is well-established. What's new about our finding is that we can visualize these vessels in minutes with a very quick scan, using very inexpensive imaging methods." Dr. Dayton is a member of UNC Lineberger Comprehensive Cancer Center.

The UNC team used a new high-resolution ultrasound method, called "acoustic angiography," with an intravascular contrast agent that allowed them to acquire images of only the blood vessels. "Unlike current clinical 'grayscale' ultrasound, this method filters out all tissue signals, so we can see small blood vessels clearly." says Dayton.

"Our results showed a definitive difference between vessels within and surrounding tumors versus those associated with normal healthy vasculature. The limitation that we must now address is that our method works only for tumors at a shallow depth into tissue, such as melanomas or thyroid cancer. Our next studies will focus on this imaging-depth issue as well as evaluating the ability of this technology to determine a tumor's response to therapy.

"We know from several clinical and preclinical MRI studies at UNC by Elizabeth Bullitt, MD, and others, and at other institutions that vessels can unbend, or "normalize," in response to effective therapy. We need to see if our inexpensive ultrasound-based method of blood vessel visualization and tortuosity analysis can detect this normalization prior to conventional assessments of tumor response to therapy, such as measurements of tumor size.


Story Source:

The above story is based on materials provided by University of North Carolina Health Care. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. C. Gessner, S. R. Aylward, P. A. Dayton. Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model. Radiology, 2012; DOI: 10.1148/radiol.12112000

Cite This Page:

University of North Carolina Health Care. "Preclinical studies use specialized ultrasound to detect presence of cancer." ScienceDaily. ScienceDaily, 10 July 2012. <www.sciencedaily.com/releases/2012/07/120710120235.htm>.
University of North Carolina Health Care. (2012, July 10). Preclinical studies use specialized ultrasound to detect presence of cancer. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/07/120710120235.htm
University of North Carolina Health Care. "Preclinical studies use specialized ultrasound to detect presence of cancer." ScienceDaily. www.sciencedaily.com/releases/2012/07/120710120235.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins