Featured Research

from universities, journals, and other organizations

Older age marker may be more appropriate in predicting papillary thyroid cancer prognosis

Date:
October 10, 2012
Source:
Thomas Jefferson University
Summary:
Researchers have shown that age 45 is no longer a useful predictor of negative outcomes in the staging of papillary thyroid cancer patients.

Researchers at Thomas Jefferson University Hospital have shown that age 45 is no longer a useful predictor of negative outcomes in the staging of papillary thyroid cancer patients.

Their findings were among the most impactful abstracts recently presented at the American Thyroid Association annual meeting in Quebec City, Quebec, Canada.

Since the 1970s, physicians have used age of diagnosis to determine the severity of thyroid cancers. Papillary Thyroid Cancers -- those including affected lymph nodes -- diagnosed before age 45 are designated as Stage 1, following the American Joint Committee on Cancer and the International Union Against Cancer TNM Classification of Malignant Tumors staging system. The same papillary thyroid cancer with lymph node involvement presenting after age 45 years is Stage 3.

With 34,000 new cases of papillary thyroid cancer diagnosed annually, the group set out to determine the scientific validity of diagnosis at 45 years of age and over as such a powerful negative prognosticator. "While this staging system was once accurate and effective, we are seeing that patients age 45-64 have similar outcomes to those under age 45 years," says Jeffrey L. Miller, MD, co-director of the Thyroid Center at Thomas Jefferson University Hospital and lead researcher on the study.

A review of the literature determined that this age marker was first set forth in a study in 1979, followed by a paper in 1993 reviewing 1,779 patients treated for papillary thyroid cancer from 1940 to 1989 to determine the variables most prognostic of mortality. When looking at age, the mortality curve seemed most pronounced in patients greater than 60 years of age. A 2005 study showed significant declines in mortality in patients greater than 45 years of age, though no statistics for other age ranges were given.

The Jefferson team subsequently analyzed thyroid cancers diagnosed between 2001 and 2007 in the Surveillance, Epidemiology and End Result (SEER) database and reviewed 5-year survival rates. Of the 45,390 cases reviewed, the most significant drop in survival rate was seen in those age 65 to 74 years, though prognosis was still good at 92.0 percent. An even more marked survival difference was noted in those diagnosed with thyroid cancer at age 75 and older at 82.2 percent.

"With time, we have developed new therapies and surgical techniques, leading to better survival rates," says Miller. "This leads many patients to have a more favorable prognosis, avoid potentially unnecessary therapies and allay patients' fears about their longevity up to age 64. We feel that age 45 is no longer an appropriate age designation to influence papillary thyroid cancer prognosis," he says.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Older age marker may be more appropriate in predicting papillary thyroid cancer prognosis." ScienceDaily. ScienceDaily, 10 October 2012. <www.sciencedaily.com/releases/2012/10/121010112258.htm>.
Thomas Jefferson University. (2012, October 10). Older age marker may be more appropriate in predicting papillary thyroid cancer prognosis. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2012/10/121010112258.htm
Thomas Jefferson University. "Older age marker may be more appropriate in predicting papillary thyroid cancer prognosis." ScienceDaily. www.sciencedaily.com/releases/2012/10/121010112258.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins