Featured Research

from universities, journals, and other organizations

Childhood cancer survivors who received chest irradiation at risk for pulmonary hypertension in middle age

Date:
February 13, 2013
Source:
St. Jude Children's Research Hospital
Summary:
Researchers have found evidence that chest irradiation may leave some adult survivors of childhood cancer in danger of developing pulmonary hypertension in middle age.

St. Jude Children's Research Hospital investigators found evidence that chest irradiation may leave some adult survivors of childhood cancer in danger of developing pulmonary hypertension in middle age.

Childhood cancer survivors treated with chest irradiation or certain chemotherapy drugs are known to be at risk for a variety of treatment-related heart problems. But the study published recently in the Journal of Clinical Oncology is the first report suggesting survivors might also face higher odds of developing pulmonary hypertension. Pulmonary hypertension is a serious, progressive form of increased pressure in the arteries in the lungs. Untreated, the problem is associated with a significant risk for heart failure and death.

The study involved 498 adult survivors who underwent echocardiography, a recommended heart screening test, which included an estimate of their pulmonary artery pressure. The test found that pulmonary artery pressure was elevated in 25 percent of survivors treated with chest irradiation. The findings suggested the survivors, whose average age was 38 years old, might be at higher risk of pulmonary hypertension. Researchers also found that the risk climbed with increasing radiation dose and was associated with decreased exercise endurance.

The findings will likely lead to revised heart screening recommendations for adult survivors of childhood cancer, as well as research to understand and effectively manage pulmonary hypertension in this newly identified high-risk group.

First author Gregory Armstrong, M.D., an associate member in the St. Jude Epidemiology and Cancer Control department, said the risk might have gone unnoticed in previous studies because survivors were younger and the screening involved a less detailed assessment of pulmonary artery pressure. "One of the keys to this study is that half the survivors are almost 30 years down the road from their diagnosis, but no one expected to see evidence of pulmonary hypertension," he said.

The risk surfaced in St. Jude Lifetime Cohort Study participants undergoing recommended Doppler echocardiography to check for premature heart disease, heart valve abnormalities and other treatment-related cardiovascular problems. The effort, known as St. Jude LIFE, is an ongoing study of St. Jude cancer survivors.

Study co-author Vijaya Joshi, M.D., St. Jude echocardiography laboratory medical director, noticed that some survivors had unexpectedly high pulmonary artery pressures.

That clinical observation led to this larger study, which linked the risk to chest irradiation and found elevated pressure occurred most often in survivors who received a radiation dose of 30 gray or more. Those survivors were almost five times more likely to have elevated pulmonary artery pressure than survivors treated without chest irradiation. They were also likely to be survivors of pediatric Hodgkin lymphoma.

Survivors with higher estimated pulmonary pressure were also less likely to complete a 300-meter walk, which is less than one-quarter mile. "This suggests survivors with this echocardiographic finding do not function as well in their daily lives," Armstrong said.


Story Source:

The above story is based on materials provided by St. Jude Children's Research Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. T. Armstrong, V. M. Joshi, L. Zhu, D. Srivastava, N. Zhang, K. K. Ness, D. C. Stokes, M. T. Krasin, J. A. Fowler, L. L. Robison, M. M. Hudson, D. M. Green. Increased Tricuspid Regurgitant Jet Velocity by Doppler Echocardiography in Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study. Journal of Clinical Oncology, 2013; DOI: 10.1200/JCO.2012.43.0702

Cite This Page:

St. Jude Children's Research Hospital. "Childhood cancer survivors who received chest irradiation at risk for pulmonary hypertension in middle age." ScienceDaily. ScienceDaily, 13 February 2013. <www.sciencedaily.com/releases/2013/02/130213114506.htm>.
St. Jude Children's Research Hospital. (2013, February 13). Childhood cancer survivors who received chest irradiation at risk for pulmonary hypertension in middle age. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/02/130213114506.htm
St. Jude Children's Research Hospital. "Childhood cancer survivors who received chest irradiation at risk for pulmonary hypertension in middle age." ScienceDaily. www.sciencedaily.com/releases/2013/02/130213114506.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins