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Doctors not informed of harmful effects of medicines during sales visits

Date:
April 10, 2013
Source:
University of British Columbia
Summary:
The majority of family doctors receive little or no information about harmful effects of medicines when visited by drug company representatives, according to a new study.

In a UBC study, doctors surveyed shortly after a promotional visit by pharmaceutical sales representatives indicate they are likely to prescribe the medicine. The study also found that in the majority of these visits, doctors weren't informed of the harmful effects of the promoted medicines.
Credit: UBC

The majority of family doctors receive little or no information about harmful effects of medicines when visited by drug company representatives, according to an international study involving Canadian, U.S. and French physicians.

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Yet the same doctors indicated that they were likely to start prescribing these drugs, consistent with previous research that shows prescribing behaviour is influenced by pharmaceutical promotion.

The study, which had doctors fill out questionnaires about each promoted medicine following sales visits, was published online today in the Journal of General Internal Medicine. It shows that sales representatives failed to provide any information about common or serious side effects and the type of patients who should not use the medicine in 59 per cent of the promotions. In Vancouver and Montreal, no potential harms were mentioned for 66 per cent of promoted medicines.

"Laws in all three countries require sales representatives to provide information on harm as well as benefits," says lead author Barbara Mintzes of the University of British Columbia. "But no one is monitoring these visits and there are next to no sanctions for misleading or inaccurate promotion."

Serious risks were mentioned in only six percent of the promotions, even though 57 per cent of the medications involved in these visits came with US Food and Drug Administration "black box" or Health Canada boxed warnings -- the strongest drug warning that can be issued by both countries.

"We are very concerned that doctors and patients are left in the dark and patient safety may be compromised," says Mintzes, an expert on drug advertising in UBC's School of Population and Public Health.

Doctors in Toulouse were more likely to be told of a harmful effect in a promotional visit, compared to doctors in Canada and the U.S., according to the study. Researchers suggested that this may reflect stricter regulatory standards for promotion of medicines in France.

About the study

The UBC-led study is the most comprehensive to date of the quality of pharmaceutical sales representative promotions to family physicians.

Researchers recruited physicians to participate using random samples from lists of primary care physicians at four sites -- Vancouver, Montreal, Sacramento and Toulouse. Among 704 eligible physicians contacted, 255 (36 per cent) chose to participate. Information was collected on 1,692 drug promotions at sales visits between May 2009 to June 2010.

Doctors were asked to fill out a questionnaire about the information provided for each promoted medicine following each visit they received from pharmaceutical sales representatives. Sales representatives regularly visit doctors' offices to promote medicines by providing information, free samples and in some cases food and invitations to events. The study focused on how often information was provided about drug safety.

The team includes researchers from UBC, York University, University of Montreal, University of California, Davis and the University of Toulouse.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Barbara Mintzes, Joel Lexchin, Jason M. Sutherland, Marie-Dominique Beaulieu, Michael S. Wilkes, Geneviève Durrieu, Ellen Reynolds. Pharmaceutical Sales Representatives and Patient Safety: A Comparative Prospective Study of Information Quality in Canada, France and the United States. Journal of General Internal Medicine, 2013; DOI: 10.1007/s11606-013-2411-7

Cite This Page:

University of British Columbia. "Doctors not informed of harmful effects of medicines during sales visits." ScienceDaily. ScienceDaily, 10 April 2013. <www.sciencedaily.com/releases/2013/04/130410094337.htm>.
University of British Columbia. (2013, April 10). Doctors not informed of harmful effects of medicines during sales visits. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/04/130410094337.htm
University of British Columbia. "Doctors not informed of harmful effects of medicines during sales visits." ScienceDaily. www.sciencedaily.com/releases/2013/04/130410094337.htm (accessed October 25, 2014).

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