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Drinking alcohol during pregnancy affects learning and memory function in offspring?

Date:
July 19, 2013
Source:
Neural Regeneration Research
Summary:
Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

A large number of hippocampal neurons were stained with cyclin-dependent kinase 5 in the offspring from the ethanol-treated group (immunofluorescence, x 400).
Credit: Neural Regeneration Research

Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development.

Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.

Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin-dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin-dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.

These findings, which reported in the Neural Regeneration Research, propose new insights into the mechanisms underlying the role of ethanol exposure in central nervous system injuries, and provide a new strategy for treating the consequences of prenatal ethanol exposure.


Story Source:

The above story is based on materials provided by Neural Regeneration Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. shuang Li, Yan Zhang, Feng Zhu, Bin Zhang, Jianying Lin, Chunyang Xu, Wancai Yang, Wei Hao, Ruiling Zhang. A new treatment for cognitive disorders related to in utero exposure to alcohol. Neural Regeneration Research, Vol. 8, No. 18, 2013 DOI: 10.3969/j.issn.1673-5374.2013.18.008

Cite This Page:

Neural Regeneration Research. "Drinking alcohol during pregnancy affects learning and memory function in offspring?." ScienceDaily. ScienceDaily, 19 July 2013. <www.sciencedaily.com/releases/2013/07/130719104937.htm>.
Neural Regeneration Research. (2013, July 19). Drinking alcohol during pregnancy affects learning and memory function in offspring?. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/07/130719104937.htm
Neural Regeneration Research. "Drinking alcohol during pregnancy affects learning and memory function in offspring?." ScienceDaily. www.sciencedaily.com/releases/2013/07/130719104937.htm (accessed April 16, 2014).

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