July 19, 2013 Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development.
Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.
Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin-dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin-dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.
These findings, which reported in the Neural Regeneration Research, propose new insights into the mechanisms underlying the role of ethanol exposure in central nervous system injuries, and provide a new strategy for treating the consequences of prenatal ethanol exposure.
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- shuang Li, Yan Zhang, Feng Zhu, Bin Zhang, Jianying Lin, Chunyang Xu, Wancai Yang, Wei Hao, Ruiling Zhang. A new treatment for cognitive disorders related to in utero exposure to alcohol. Neural Regeneration Research, Vol. 8, No. 18, 2013 DOI: 10.3969/j.issn.1673-5374.2013.18.008
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