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A ginkgo biloba extract promotes proliferation of endogenous neural stem cells

Date:
July 23, 2013
Source:
Neural Regeneration Research
Summary:
Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia.

Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia.

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Prof. Yuliang Wang and team from Weifang Medical University observed the effects of EGb761 on proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. Researchers found that the ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. The cells continued to proliferate at 4 months. EGb761 also significantly improved learning and memory in rats with vascular dementia.

These findings which were published in the Neural Regeneration Research (Vol. 8, No. 18, 2013) provide a new idea and approach to further explore the induced proliferation of neural stem cells in situ in the treatment of vascular dementia.


Story Source:

The above story is based on materials provided by Neural Regeneration Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wang JW, Chen W, Wang YL. A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats. Neural Regeneration Research, 2013; 8 (18): 1655-1662 DOI: 10.3969/j.issn.1673-5374.2013.18.003

Cite This Page:

Neural Regeneration Research. "A ginkgo biloba extract promotes proliferation of endogenous neural stem cells." ScienceDaily. ScienceDaily, 23 July 2013. <www.sciencedaily.com/releases/2013/07/130723113701.htm>.
Neural Regeneration Research. (2013, July 23). A ginkgo biloba extract promotes proliferation of endogenous neural stem cells. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/07/130723113701.htm
Neural Regeneration Research. "A ginkgo biloba extract promotes proliferation of endogenous neural stem cells." ScienceDaily. www.sciencedaily.com/releases/2013/07/130723113701.htm (accessed November 24, 2014).

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