Save
Email
Print
ShareJuly 23, 2013 — Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia.
Prof. Yuliang Wang and team from Weifang Medical University observed the effects of EGb761 on proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. Researchers found that the ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. The cells continued to proliferate at 4 months. EGb761 also significantly improved learning and memory in rats with vascular dementia.
These findings which were published in the Neural Regeneration Research (Vol. 8, No. 18, 2013) provide a new idea and approach to further explore the induced proliferation of neural stem cells in situ in the treatment of vascular dementia.
Other social bookmarking and sharing tools:
Story Source:
The above story is based on materials provided by Neural Regeneration Research, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Wang JW, Chen W, Wang YL. A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats. Neural Regeneration Research, 2013; 8 (18): 1655-1662 DOI: 10.3969/j.issn.1673-5374.2013.18.003
Note: If no author is given, the source is cited instead.
more 
