Featured Research

from universities, journals, and other organizations

Brain atrophy linked with cognitive decline in diabetes

Date:
September 12, 2013
Source:
Monash University
Summary:
New research has shown that cognitive decline in people with type 2 diabetes is likely due to brain atrophy, or shrinkage, that resembles patterns seen in the early stages of Alzheimer's disease.

Areas of brain susceptible to atrophy linked to Type 2 diabetes.
Credit: Monash University

New research has shown that cognitive decline in people with Type 2 Diabetes is likely due to brain atrophy, or shrinkage, that resembles patterns seen in the early stages of Alzheimer's disease.

Dr Chris Moran and Associate Professor Velandai Srikanth of Monash University led the first large-scale study to compare brain scans and cognitive function between people with and without Type 2 Diabetes Mellitus (T2DM). They found that brain atrophy, rather than cerebrovascular lesions, was likely the primary reason for cognitive impairment associated with T2DM.

The World Health Organisation reports that more that more than 347 million people worldwide live with diabetes and around 90 per cent of these cases are Type 2.

Associate Professor Velandai Srikanth of Monash University's Department of Medicine said the findings had important implications for Australia's aging population.

"Type 2 Diabetes and dementia are both highly common disorders affecting the aging population and this research shows that there may be a mechanistic link between them. Indeed, generalised brain atrophy may be the key driver of cognitive decline in Type 2 diabetes and such atrophy is also commonly seen in people with dementia," Associate Professor Srikanth said.

"By 2031 it is estimated that around 3.3 million Australians will have diabetes. The burden of dementia in the population will be greatly increased if a significant number of these individuals experience cognitive decline."

The research built on previous studies that had shown there may be a greater risk of future dementia in people with T2DM. However, it was unclear whether T2DM was a causal factor for the development of cognitive impairment, and if so, what mechanisms may be involved.

The researchers compared cognitive function and Magnetic Resonance Imaging (MRI) scans of the brain in more than 700 people with and without T2DM.

Those with diabetes performed less well in certain cognitive tests and had greater shrinkage in specific regions of the brain, which appeared to drive the differences in cognitive function. Although the researchers found that participants with diabetes also had more strokes on MRI, this did not explain the cognitive differences between groups.

The findings, published in Diabetes Care, will lead further research in trying to identify why people with Type 2 Diabetes develop brain atrophy, and how such atrophy may be prevented or slowed.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Moran, T. G. Phan, J. Chen, L. Blizzard, R. Beare, A. Venn, G. Munch, A. G. Wood, J. Forbes, T. M. Greenaway, S. Pearson, V. Srikanth. Brain Atrophy in Type 2 Diabetes: Regional distribution and influence on cognition. Diabetes Care, 2013; DOI: 10.2337/dc13-0143

Cite This Page:

Monash University. "Brain atrophy linked with cognitive decline in diabetes." ScienceDaily. ScienceDaily, 12 September 2013. <www.sciencedaily.com/releases/2013/09/130912093807.htm>.
Monash University. (2013, September 12). Brain atrophy linked with cognitive decline in diabetes. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2013/09/130912093807.htm
Monash University. "Brain atrophy linked with cognitive decline in diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/09/130912093807.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins