Featured Research

from universities, journals, and other organizations

In elderly, hardening of arteries linked to plaques in brain

Date:
October 16, 2013
Source:
American Academy of Neurology (AAN)
Summary:
Even for elderly people with no signs of dementia, those with hardening of the arteries are more likely to also have the beta-amyloid plaques in the brain that are a hallmark of Alzheimer’s disease.

Even for elderly people with no signs of dementia, those with hardening of the arteries are more likely to also have the beta-amyloid plaques in the brain that are a hallmark of Alzheimer's disease, according to a study published in the October 16, 2013, online issue of Neurology, the medical journal of the American Academy of Neurology.

"This is more evidence that cardiovascular health leads to a healthy brain," said study author Timothy M. Hughes, PhD, of the University of Pittsburgh.

The study involved 91 people with an average age of 87 who did not have dementia. Researchers took scans of the participants' brains to measure any plaques in the brain. The amount of stiffness in the participants' arteries was measured about two years later.

Half of all participants had beta-amyloid plaques. People with beta-amyloid plaques were more likely to have high systolic blood pressure, higher average blood pressure and higher arterial stiffness as measured with the brachial-ankle method. For every unit increase in brachial-ankle arterial stiffness, people were twice as likely to have beta-amyloid plaques in the brain.

Arterial stiffness was highest in people who had both amyloid plaques and white matter hyperintensities in the brain, or brain lesions.

"These two conditions may be a 'double-hit' that contributes to the development of dementia," Hughes said. "Compared to people who had low amounts of amyloid plaques and brain lesions, each unit of increase in arterial stiffness was associated with a two- to four-fold increase in the odds of having both amyloid plaques and a high amount of brain lesions."

Hughes noted that the relationship between arterial stiffness and amyloid plaque was not changed when regular resting blood pressure was taken into account. "This study adds to growing evidence that hardening of the arteries is associated with cerebrovascular disease that does not show symptoms. Now we can add Alzheimer's type lesions to the list," Hughes said.


Story Source:

The above story is based on materials provided by American Academy of Neurology (AAN). Note: Materials may be edited for content and length.


Journal Reference:

  1. T. M. Hughes, L. H. Kuller, E. J. M. Barinas-Mitchell, R. H. Mackey, E. M. McDade, W. E. Klunk, H. J. Aizenstein, A. D. Cohen, B. E. Snitz, C. A. Mathis, S. T. DeKosky, O. L. Lopez. Pulse wave velocity is associated with -amyloid deposition in the brains of very elderly adults. Neurology, 2013; DOI: 10.1212/01.wnl.0000435301.64776.37

Cite This Page:

American Academy of Neurology (AAN). "In elderly, hardening of arteries linked to plaques in brain." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016212443.htm>.
American Academy of Neurology (AAN). (2013, October 16). In elderly, hardening of arteries linked to plaques in brain. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/10/131016212443.htm
American Academy of Neurology (AAN). "In elderly, hardening of arteries linked to plaques in brain." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016212443.htm (accessed April 18, 2014).

Share This



More Mind & Brain News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study On Artists' Brain Shows They're 'Structurally Unique'

Study On Artists' Brain Shows They're 'Structurally Unique'

Newsy (Apr. 17, 2014) The brains of artists aren't really left-brain or right-brain, but rather have extra neural matter in visual and motor control areas. Video provided by Newsy
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Are School Dress Codes Too Strict?

Are School Dress Codes Too Strict?

AP (Apr. 16, 2014) Pushing the limits on style and self-expression is a rite of passage for teens and even younger kids. How far should schools go with their dress codes? The courts have sided with schools in an era when school safety is paramount. (April 16) Video provided by AP
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins