Featured Research

from universities, journals, and other organizations

New findings on women, pregnancy, epilepsy

Date:
December 9, 2013
Source:
American Epilepsy Society (AES)
Summary:
New research pertaining to the latest findings on the effects of epilepsy on both the mother and child explore folic acid use, the effect of surgery with intractable focal epilepsy, and antiepileptic drug exposure during breastfeeding.

New research pertaining to the latest findings on the effects of epilepsy on both the mother and child were presented at the American Epilepsy Society's 67th Annual Meeting in Washington DC. These studies explore folic acid use, the effect of surgery with intractable focal epilepsy, and antiepileptic drug exposure during breastfeeding.

Researchers from the Harvard Neuroendocrine Unit at Beth Israel Deaconess Medical Center in Boston, Massachusetts investigated the frequency of folic acid supplement use by women with epilepsy in the community and factors that may predict its use. Folic acid deficiency in early pregnancy is known to cause birth defects and increase the risk of miscarriages, which can occur most with enzyme-inducing antiepileptic drugs (AED). Neural tube malformations are most common with the use of Valproate, a folic acid antagonist.

Data for this study was collected through the Epilepsy Birth Control Registry (EBCR), a web-based survey and educational site used to gather key information from 626 women with epilepsy in the community. The study found that 44% of respondents took folic acid.

"Our findings show that only about half of the women surveyed are taking folic acid, despite their high risk of unintended pregnancies. Additionally, we found that many of the respondents who were not taking precaution of neural tube malformation were taking Valproate, a folic acid antagonist," said Andrew G. Herzog, MD, principal investigator of the study. "Overall the women at risk, regardless of antiepileptic drugs or contraceptive use, did not differ significantly from women not at risk and on no antiepileptic drugs."

In a related study, researchers from The Mayo Clinic-Rochester presented evidence to support the importance of early surgery in women with intractable focal epilepsy looking to get pregnant. One hundred and thirteen women were included in this study. An average of 0.93 pregnancies and 0.73 births were identified prior to surgery, compared to a significantly higher success rate of 1.27 pregnancies and 0.96 births post-surgery. A total of 17 women had a total of 35 pregnancies and 25 births after surgery. Those patients who received fewer medications prior to surgery were more likely to have additional children following surgery.

"While the significance of these findings is uncertain, we believe that they support a role for earlier surgical intervention in the management of intractable focal epilepsy and the relationship it has to conceiving and giving birth," said Rachel R. Fabris, MD, the lead author of this study.

A third study was presented as a follow up to previous research determining the effects of antiepileptic drug exposure via breast milk on IQ at age 3 years old. The new data collected was from a cohort of children at the age of 6, which the researchers deemed an age more predictive of school performance and adult abilities. While breastfeeding is known to have beneficial effects for both the child and the mother, there is concern regarding whether breastfeeding while taking antiepileptic drugs could be harmful to the cognitive development of the infant.

Results of the study were analyzed as a function of whether the children had been breastfed or not. Overall, 43% of the children were breastfed, but the results failed to show adverse effects of AED exposure: children who breastfed exhibited higher IQ and Verbal Index scores even though their mothers used AEDs.

"Our results are encouraging in that women with epilepsy can be less fearful of breastfeeding their baby," said the leader of this study, Kimford Meador, MD. "Nevertheless, this is a limited study and additional research is needed."


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "New findings on women, pregnancy, epilepsy." ScienceDaily. ScienceDaily, 9 December 2013. <www.sciencedaily.com/releases/2013/12/131209132444.htm>.
American Epilepsy Society (AES). (2013, December 9). New findings on women, pregnancy, epilepsy. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2013/12/131209132444.htm
American Epilepsy Society (AES). "New findings on women, pregnancy, epilepsy." ScienceDaily. www.sciencedaily.com/releases/2013/12/131209132444.htm (accessed August 22, 2014).

Share This




More Mind & Brain News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins