Featured Research

from universities, journals, and other organizations

Chemical imaging brings cancer tissue analysis into digital age

Date:
January 8, 2014
Source:
Imperial College London
Summary:
A new method for analyzing biological samples based on their chemical makeup is set to transform the way medical scientists examine diseased tissue.

When tests are carried out on a patient's tissue today, such as to look for cancer, the test has to be interpreted by a histology specialist, and can take weeks to obtain a full result.

Mass spectrometry imaging (MSI) uses technologies that reveal how hundreds or thousands of chemical components are distributed in a tissue sample. Scientists have proposed using MSI to identify tissue types for many years, but until now, no method has been devised to apply such technology to any type of tissue.

In this week's Proceedings of the National Academy of Sciences, researchers at Imperial College London have outlined a recipe for processing MSI data and building a database of tissue types.

In MSI, a beam moves across the surface of a sample, producing a pixelated image. Each pixel contains data on thousands of chemicals present in that part of the sample. By analyzing many samples and comparing them to the results of traditional histological analysis, a computer can learn to identify different types of tissue.

A single test taking a few hours can provide much more detailed information than standard histological tests, for example showing not just if a tissue is cancerous, what the type and sub-type of cancer, which can be important for choosing the best treatment. The technology can also be applied in research to offer new insights into cancer biology.

Dr Kirill Veselkov, corresponding author of the study from the Department of Surgery and Cancer at Imperial College London, said: "MSI is an extremely promising technology, but the analysis required to provide information that doctors or scientists can interpret easily is very complex. This work overcomes some of the obstacles to translating MSI's potential into the clinic. It's the first step towards creating the next generation of fully automated histological analysis."

Dr Zoltan Takats, from the Department of Surgery and Cancer at Imperial College London, said: "This technology can change the fundamental paradigm of histology. Instead of defining tissue types by their structure, we can define them by their chemical composition. This method is independent of the user -- it's based on numerical data, rather than a specialist's eyes -- and it can tell you much more in one test than histology can show in many tests."

Professor Jeremy Nicholson, Head of the Department of Surgery and Cancer at Imperial College London, said: "There have been relatively few major changes in the way we study tissue sample pathology since the late 19th century, when staining techniques were used to show tissue structure. Such staining methods are still the mainstay of hospital histopathology; they have become much more sophisticated but they are slow and expensive to do and require considerable expertise to interpret.

"Multivariate chemical imaging that can sense abnormal tissue chemistry in one clean sweep offers a transformative opportunity in terms of diagnostic range, speed and cost, which is likely to impact on future pathology services and to improve patient safety."

The technology will also be useful in drug development. To study where a new drug is absorbed in the body, pharmaceutical scientists attach a radioactive label to the drug molecule, then look at where the radiation can be detected in a laboratory animal. If the label is detached when the drug is processed in the body, it is impossible to determine how and where the drug has been metabolised. MSI would allow researchers to look for the drug and any metabolic products in the body, without using radioactive labels.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. A. Veselkov, R. Mirnezami, N. Strittmatter, R. D. Goldin, J. Kinross, A. V. M. Speller, T. Abramov, E. A. Jones, A. Darzi, E. Holmes, J. K. Nicholson, Z. Takats. Chemo-informatic strategy for imaging mass spectrometry-based hyperspectral profiling of lipid signatures in colorectal cancer. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1310524111

Cite This Page:

Imperial College London. "Chemical imaging brings cancer tissue analysis into digital age." ScienceDaily. ScienceDaily, 8 January 2014. <www.sciencedaily.com/releases/2014/01/140108102447.htm>.
Imperial College London. (2014, January 8). Chemical imaging brings cancer tissue analysis into digital age. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/01/140108102447.htm
Imperial College London. "Chemical imaging brings cancer tissue analysis into digital age." ScienceDaily. www.sciencedaily.com/releases/2014/01/140108102447.htm (accessed July 28, 2014).

Share This




More Matter & Energy News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Lithium Battery 'Holy Grail' Could Provide 4 Times The Power

Lithium Battery 'Holy Grail' Could Provide 4 Times The Power

Newsy (July 28, 2014) Stanford University published its findings for a "pure" lithium ion battery that could have our everyday devices and electric cars running longer. Video provided by Newsy
Powered by NewsLook.com
The Carbon Trap: US Exports Global Warming

The Carbon Trap: US Exports Global Warming

AP (July 28, 2014) AP Investigation: As the Obama administration weans the country off dirty fuels, energy companies are ramping-up overseas coal exports at a heavy price. (July 28) Video provided by AP
Powered by NewsLook.com
Shipping Crates Get New 'lease' On Life

Shipping Crates Get New 'lease' On Life

Reuters - Business Video Online (July 25, 2014) Shipping containers have been piling up as America imports more than it exports. Some university students in Washington D.C. are set to get a first-hand lesson in recycling. Their housing is being built using refashioned shipping containers. Lily Jamali reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Highest Train Turns 80 in French Pyrenees

Europe's Highest Train Turns 80 in French Pyrenees

AFP (July 25, 2014) Europe's highest train, the little train of Artouste in the French Pyrenees, celebrates its 80th birthday. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins