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Optimizing donor kidney distribution in the United States

Date:
February 14, 2014
Source:
Northwestern University
Summary:
Nearly 5,000 people die each year in the US waiting for a kidney transplant. A researcher has now developed a mathematical model that simulates and optimizes donor kidney distribution. The model identifies areas for policy changes, including encouraging more sharing within states. The innovative model could help ease inequities among regions in the US and ultimately help save hundreds of lives.

Northwestern University's Sanjay Mehrotra has developed an innovative model that could help ease kidney distribution inequities among regions in the U.S. and ultimately help save hundreds of lives. His mathematical model, which takes into account a number of different factors, simulates and optimizes donor kidney distribution.

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Mehrotra will discuss his research in a presentation titled "Addressing Allocation Inefficiencies and Geographic Disparities" at the American Association for the Advancement of Science (AAAS) annual meeting in Chicago. His presentation is part of a symposium titled "Transplant Organ Shortage: Informing National Policies Using Management Sciences" to be held from 10 to 11:30 a.m. CST Friday, Feb. 14, in Columbus IJ of the Hyatt Regency Chicago.

Mehrotra also will participate in a press briefing to be held at 1 p.m. CST the same day in Vevey Room 3 of the Swissôtel Chicago.

In addition to Mehrotra, two other Northwestern professors will discuss issues related to organ shortage during both the symposium and press briefing.

Michael Abecassis, M.D., chief of the division of organ transplantation and founding director of the Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine, will offer a brief overview of the current issues facing organ allocation.

John Friedewald, M.D., associate professor in medicine and surgery at Feinberg and director of clinical research at Northwestern University Feinberg School of Medicine Comprehensive Transplant Center and transplant nephrologist at Northwestern Memorial Hospital, will speak about policy changes in kidney allocation that were developed during his recent term as chair of the United Network for Organ Sharing Kidney Transplantation Committee.

Nearly 100,000 people in the United States are waiting for kidney transplants, but only 17,000 kidneys are available annually from both living and deceased donors. There are major regional inequalities in access to organs because of supply and demand disparities among different areas of the country. A person in one state might get a kidney within a year, while someone in another state might wait up to four years. As a consequence, nearly 5,000 people die each year waiting for a kidney transplant.

Logistically, organ allocation is a difficult problem. The country is divided into 11 transplant regions (which are themselves divided into 58 donor service areas). Because patients must provide biological samples to their specific transplant center beforehand, and because kidney donations must happen within 24 hours of harvesting, most kidneys are distributed within the same geographic zone in which they are donated. But regions vary in how many kidneys they receive a year, and centers differ in the quality of kidneys they accept for transplant.

Mehrotra, a professor of industrial engineering and management sciences at Northwestern's McCormick School of Engineering and Applied Science, provides a solution by combining each of these factors into a model that can optimize distribution.

His model identifies areas for policy changes, including encouraging more sharing within states, encouraging transplant centers with long wait times to transplant lower-quality kidneys and encouraging insurance companies to weigh the cost-benefit analysis of dialysis versus transplanting lower-quality kidneys.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "Optimizing donor kidney distribution in the United States." ScienceDaily. ScienceDaily, 14 February 2014. <www.sciencedaily.com/releases/2014/02/140214111100.htm>.
Northwestern University. (2014, February 14). Optimizing donor kidney distribution in the United States. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/02/140214111100.htm
Northwestern University. "Optimizing donor kidney distribution in the United States." ScienceDaily. www.sciencedaily.com/releases/2014/02/140214111100.htm (accessed November 27, 2014).

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