Featured Research

from universities, journals, and other organizations

Understanding heart failure at the cellular level

Date:
February 19, 2014
Source:
Biophysical Society
Summary:
Scientists have provided an unprecedented glimpse of what happens to the heart during an "infarction" -- a heart attack -- by looking at how the attack affects electrical activity and calcium release in heart cells.

A team of researchers at the University of Florence in Italy and the University of Connecticut Health Center have used a multidisciplinary approach to provide an unprecedented glimpse of what happens to the heart during an "infarction" -- a heart attack -- by looking at how the attack affects electrical activity and calcium release in heart cells.

"Thanks to this method, we found electrical abnormalities and non-homogenous calcium release across failing cells," explained Claudia Crocini, who will be presenting the research at the 58th Annual Biophysical Society Meeting, taking place in San Francisco from Feb. 15-19. "Our findings provide insight on the relationship between heart failure and asynchronous calcium release, a major determinant of cardiac contractile dysfunction and arrhythmias."

Heart disease is the leading cause of death in the United States, accounting for a quarter of all American deaths each year and costing the healthcare system more than $100 billion annually. According to the American Heart Association, there are 5.7 million Americans who are living with heart failure and 670,000 new cases are diagnosed annually.

Seeking to understand what happens to heart cells during heart failure, Crocini and her colleagues took a multidisciplinary approach involving physicists and biologists that made it possible to study the two main features of cardiac cells, voltage and calcium release, during heart failure with an unprecedented temporal and spatial resolution.

To clarify the link between electrical abnormalities and calcium-dependent arrhythmias, the team combined the advantages of an ultrafast random access multi-photon (RAMP) microscope with a double staining approach to optically record action potential and, simultaneously, the corresponding local Ca2+-transient in different positions across the cardiac cells.

Both beat-to-beat and spatial variability of Ca2+-transient kinetics were increased in heart failure. Through simultaneous recording of AP and Ca2+-transient the team was able to probe the spatio-temporal variability of Ca2+-release, disclosing an unexpected uncoupling between membrane depolarization and Ca2+-release in heart failure. "While there is not a direct bench-to-bedside connection for this research, it is only by studying the basic pathomechanisms of heart failure that we can even begin to think about new diagnostic or treatment approaches," said Crocini.


Story Source:

The above story is based on materials provided by Biophysical Society. Note: Materials may be edited for content and length.


Cite This Page:

Biophysical Society. "Understanding heart failure at the cellular level." ScienceDaily. ScienceDaily, 19 February 2014. <www.sciencedaily.com/releases/2014/02/140219075113.htm>.
Biophysical Society. (2014, February 19). Understanding heart failure at the cellular level. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/02/140219075113.htm
Biophysical Society. "Understanding heart failure at the cellular level." ScienceDaily. www.sciencedaily.com/releases/2014/02/140219075113.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins