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Impact of head movement on fMRI data shown in new study

Date:
February 19, 2014
Source:
Kessler Foundation
Summary:
Discarding data from subjects with multiple sclerosis who exhibit head movement during functional magnetic resonance imaging may bias sampling away from subjects with lower cognitive ability, new research has shown. Because head movement during fMRI degrades data quality, data associated with severe movement is frequently discarded as a source of random error, and these authors note that it is important for researchers to be aware of this potential bias.
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Kessler Foundation researchers have shown that discarding data from subjects with multiple sclerosis (MS) who exhibit head movement during functional magnetic resonance imaging (fMRI) may bias sampling away from subjects with lower cognitive ability. The study was published in the January issue of Human Brain Mapping. Glenn Wylie, DPhil, is associate director of Neuroscience in Neuropsychology & Neuroscience Research at Kessler Foundation. He is also associate director of the Neuroimaging Center at Kessler Foundation, and an associate professor at Rutgers -- New Jersey Medical School.

Because head movement during fMRI degrades data quality, data associated with severe movement is frequently discarded as a source of random error. Kessler Foundation scientists tested this assumption in 34 persons with MS by examining whether head movement was related to task difficulty and cognitive status. Cognitive status was assessed by combining performance on a working memory and processing speed task.

"We found an interaction between task difficulty and cognitive status," explained Dr. Wylie. "As task difficulty increased, there was a linear increase in movement that was larger among subjects with lower cognitive ability." Healthy controls showed similar, though far smaller, effects. This finding indicates that discarding data with severe movement artifact may bias MS samples such that only subjects with less-severe cognitive impairment are included in the analyses. However, even if such data are not discarded outright, subjects who move more will contribute less to the group-level results because of the poor quality of their data.

It is important for researchers to be aware of this potential bias. "Some newer scanners can correct for motion," noted Dr Wylie. "Another approach is to monitor each subject's motion parameters and ensure that an adequate number of subjects with low cognition are included. Recruiting a large number of subjects may ensure inclusion of a sufficient number of people with low cognition/low movement. It is however, a costly option."


Story Source:

The above post is reprinted from materials provided by Kessler Foundation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Glenn R. Wylie, Helen Genova, John DeLuca, Nancy Chiaravalloti, James F. Sumowski. Functional magnetic resonance imaging movers and shakers: Does subject-movement cause sampling bias? Human Brain Mapping, 2014; 35 (1): 1 DOI: 10.1002/hbm.22150

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Kessler Foundation. "Impact of head movement on fMRI data shown in new study." ScienceDaily. ScienceDaily, 19 February 2014. <www.sciencedaily.com/releases/2014/02/140219124738.htm>.
Kessler Foundation. (2014, February 19). Impact of head movement on fMRI data shown in new study. ScienceDaily. Retrieved August 30, 2015 from www.sciencedaily.com/releases/2014/02/140219124738.htm
Kessler Foundation. "Impact of head movement on fMRI data shown in new study." ScienceDaily. www.sciencedaily.com/releases/2014/02/140219124738.htm (accessed August 30, 2015).

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