Featured Research

from universities, journals, and other organizations

Alzheimer's disease progression and its physiological aging: New therapeutic scenario?

Date:
March 19, 2014
Source:
Sbarro Health Research Organization (SHRO)
Summary:
The role of 4-HNE and PPAR beta/delta during Alzheimer's disease progression and in physiological aging have been studied in recent research. The data obtained using a special AD animal model, indicate a novel destructive age-dependent role of PPAR beta/delta in AD. This finding may have important implications for the prevention of cognitive impairment in elderly and in neurodegenerative diseases.

Oxidative stress, an imbalance of pro-oxidants and antioxidants, is linked to aging and many neurological disorders such as Alzheimer's disease, the most common form of dementia. In the recent years, a number of scientific publications have reported that PPARs, a group of nuclear receptor proteins controlling gene activity within our body, play an important role at normal and pathological levels in different tissues, including the nervous tissue. In fact, their involvement in neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's, Parkinson's and Huntington's diseases, is well recognized.

Related Articles


More, 4-HNE, a substance that initiates a physiological response when combined with one type of PPARs molecules, namely PPARβ/δ, is known to be involved in neurodegenerative diseases as well. Now, a new study from the Sbarro Health Research Organization and the University of L'Aquila (Italy) has investigated the role of 4-HNE and PPAR β/δ during AD progression and in physiological aging.

The data obtained using a special AD animal model, indicate a novel destructive age-dependent role of PPAR β/δ in AD. This finding just published on Cell Cycle, may have important implications for the prevention of cognitive impairment in elderly and in neurodegenerative diseases.

"Our studies point towards the possibility to use a specific PPARβ/δ antagonist for counteracting the disease progression" says Annamaria Cimini of the University of L'Aquila, lead author of the study. "Understanding the mechanism of action of physiological and pathological aging may provide a means to limit cognitive impairment progression" says Antonio Giordano, founder and President of the Sbarro Health Research Organization.

The abstract to the article is available at: https://www.landesbioscience.com/journals/cc/article/28295/


Story Source:

The above story is based on materials provided by Sbarro Health Research Organization (SHRO). Note: Materials may be edited for content and length.


Journal Reference:

  1. Elisabetta Benedetti, Barbara D’Angelo, Loredana Cristiano, Erica Di Giacomo, Francesca Fanelli, Sandra Moreno, Francesco Cecconi, Alessia Fidoamore, Andrea Antonosante, Roberta Falcone, Rodolfo Ippoliti, Antonio Giordano, Annamaria Cimini. Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE). Cell Cycle, March 2014

Cite This Page:

Sbarro Health Research Organization (SHRO). "Alzheimer's disease progression and its physiological aging: New therapeutic scenario?." ScienceDaily. ScienceDaily, 19 March 2014. <www.sciencedaily.com/releases/2014/03/140319093800.htm>.
Sbarro Health Research Organization (SHRO). (2014, March 19). Alzheimer's disease progression and its physiological aging: New therapeutic scenario?. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2014/03/140319093800.htm
Sbarro Health Research Organization (SHRO). "Alzheimer's disease progression and its physiological aging: New therapeutic scenario?." ScienceDaily. www.sciencedaily.com/releases/2014/03/140319093800.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com
Researchers Replace Damaged Hands With Prostheses

Researchers Replace Damaged Hands With Prostheses

Newsy (Feb. 25, 2015) Scientists in Austria have been able to fit patients who&apos;ve lost the use of a hand with bionic prostheses the patients control with their minds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins