Featured Research

from universities, journals, and other organizations

Factor present in gestational, type 2 diabetes could provide new treatment options

Date:
April 1, 2014
Source:
Cell Press
Summary:
Both pregnant women with diabetes and with type 2 diabetics have high levels of a fat metabolite that impairs pancreatic cells from secreting insulin. These findings suggest that blocking the effects of this fat metabolite may help prevent and treat diabetes.

New research reveals that both pregnant women with diabetes and with type 2 diabetics have high levels of a fat metabolite that impairs pancreatic cells from secreting insulin. The findings, which are published in the April 1 issue of the Cell Press journal Cell Metabolism, suggest that blocking the effects of this fat metabolite may help prevent and treat diabetes.

Related Articles


In nearly one-fifth of pregnancies, diabetes can arise (called gestational diabetes), and when this happens, it puts the woman at an increased risk for developing type 2 diabetes later in life. To gain better insights into the shared mechanisms behind these two types of diabetes, researchers in Dr. Michael Wheeler's lab at the University of Toronto examined more than 340 molecules in blood samples from individuals with gestational diabetes, individuals with type 2 diabetes, and individuals without diabetes. The researchers used a metabolomics approach, which involves the study of chemical processes involving metabolites.

The team found that the blood of both gestational and type 2 diabetic patients contained a remarkable number of changed metabolites, including sugars, amino acids, and fats, compared with samples from nondiabetic controls. One particular fat metabolite, called CMPF, was dramatically increased in both gestational and type 2 diabetic individuals compared to those without diabetes. Experiments in mice showed that this increased concentration of CMPF caused a decrease in insulin secretion from beta cells in the pancreas, which led to the development of diabetes.

More detailed mechanistic experiments revealed that CMPF enters a beta cell through what's called organic anion transporter 3 (OAT3), and once inside the cell it causes oxidative stress and other negative effects. Next, the researchers found that the effects of CMPF could be prevented through either blocking the transport of CMPF into insulin-producing beta cells or treatment with antioxidants.

"Based on our findings we believe that CMPF and its transporter OAT3 represent novel targets for prevention and treatment of diabetes," says first author Kacey Prentice. "If we can reduce levels of CMPF in the blood, or prevent CMPF from entering the beta cell through blockage of OAT3, we believe that we can preserve beta cell function and prevent the beta cell failure that ultimately causes diabetes."

According to Prentice, it is important to note that the treatment of gestational diabetes is a very sensitive topic due to potential risks to both the mother and the developing fetus. "Due to this, we believe the prevention and treatment of type 2 diabetes is a more realistic and widely acceptable goal; however, CMPF has great potential for use as a biomarker of both conditions."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. KaceyJ. Prentice, Lemieux Luu, EmmaM. Allister, Ying Liu, LucyS. Jun, KyleW. Sloop, AlexandreB. Hardy, Li Wei, Weiping Jia, I.George Fantus, DouglasH. Sweet, Gary Sweeney, Ravi Retnakaran, FeihanF. Dai, MichaelB. Wheeler. The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction. Cell Metabolism, 2014; 19 (4): 653 DOI: 10.1016/j.cmet.2014.03.008

Cite This Page:

Cell Press. "Factor present in gestational, type 2 diabetes could provide new treatment options." ScienceDaily. ScienceDaily, 1 April 2014. <www.sciencedaily.com/releases/2014/04/140401122359.htm>.
Cell Press. (2014, April 1). Factor present in gestational, type 2 diabetes could provide new treatment options. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/04/140401122359.htm
Cell Press. "Factor present in gestational, type 2 diabetes could provide new treatment options." ScienceDaily. www.sciencedaily.com/releases/2014/04/140401122359.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins