Featured Research

from universities, journals, and other organizations

Dermatologists with access to sample drugs write costlier prescriptions, study finds

Date:
April 16, 2014
Source:
Stanford University Medical Center
Summary:
Dermatologists with access to free drug samples are more likely than those without access to samples to write prescriptions for drugs that are more expensive, according to a study. Although studies have shown that most physicians do not believe that the availability of free samples affects their behavior or recommendations for patients, the researchers found that the average retail cost of the prescriptions written by dermatologists with access to samples are about twice the cost of prescriptions written by dermatologists at an academic medical center where such samples are prohibited.

Dermatologists with access to free drug samples are more likely than those without access to samples to write prescriptions for drugs that are more expensive, according to a study by researchers at the Stanford University School of Medicine.

Related Articles


Although studies have shown that most physicians do not believe that the availability of free samples affects their behavior or recommendations for patients, the researchers found that the average retail cost of the prescriptions written by dermatologists with access to samples are about twice the cost of prescriptions written by dermatologists at an academic medical center where such samples are prohibited.

The results of the study, which will be published April 16 in JAMA Dermatology, are likely to add fuel to an ongoing debate about whether free drug samples are beneficial or instead skew the prescription tendencies of doctors to favor brand name drugs at the expense of patients and their health insurance companies.

"Physicians may not be aware of the cost difference between brand-name and generic drugs," said Alfred Lane, MD, emeritus professor of dermatology and of pediatrics at Stanford, "and patients may not realize that, by accepting samples, they could be unintentionally channeled into subsequently receiving a prescription for a more expensive medication."

Lane is the senior author of the study. Medical student Michael Hurley is the first author.

The researchers found that branded drugs (those still under patent to a particular company) and branded generics (a term that describes an alternative dosage or new formulation of an off-patent drug sold under a new name) comprised 79 percent of prescriptions written by dermatologists nationwide, but only 17 percent of those written by physicians at an academic medical center that prohibits its physicians from accepting drug samples. Branded drugs and branded generic drugs often have similar retail prices.

In contrast to some medical specialties, the percentage of prescriptions written with a sample by dermatologists increased from 2001 to 2010 from 12 to 18 percent. (The proportion for all other specialties decreased during the same time period from 7 to 4 percent.)

The impetus for the study was a policy instituted in 2006 by Stanford Medicine, prohibiting its physicians from accepting samples or other industry gifts. After the change, Lane noticed a discrepancy between the medications he tended to prescribe and those prescribed by other physicians in the community.

"I realized that patients were referred to Stanford with prescriptions for newly introduced, branded generics that were unfamiliar to me," Lane said. "Sometimes I had to look up what they actually were. It wasn't clear to me that there was much benefit to these drugs, and they were definitely very expensive."

Pharmaceutical companies give about $16 billion in free drug samples to doctors every year, according to some studies. Doctors and patients who receive the samples appreciate the option of trying out a medication to see if it works for a particular patient before paying for a prescription, and many clinicians feel this is a cost-effective way to help poorer patients who may not have insurance, or to allow a patient to choose a preferred medication to which he or she is most likely to adhere. However, Lane began to suspect that the availability of the samples may make it more likely for a doctor to prescribe a branded, or a branded generic, drug than to explore much cheaper generic drugs that could be just as effective.

"Many physicians believe that free samples have both benefits and drawbacks," said Hurley. "Primarily, they feel that the samples give them more freedom and flexibility to help people who are uninsured, or with less financial means. But the national data don't really support that. Those people are not the ones who are typically getting these samples."

Opponents of drug samples argue that doctors may not take as much care describing sample medications and their effects as they would for non-sample medications, and that the samples serve as a form of marketing to both doctors and patients to influence treatment decisions.

Lane and Hurley focused their study on medications prescribed to treat adult acne. They examined the prescribing patterns of dermatologists nationwide in a database called the National Disease and Therapeutic Index, which represents the results of a survey of primarily office-based physicians. Participating doctors regularly self-report many aspects of their clinical encounters, including whether they wrote a prescription for a particular drug (without also giving a sample), gave a sample of a medication (without writing a prescription), or gave both a sample of and a prescription for the same drug -- that is, wrote a prescription with a sample.

In 2001, 2005 and 2010, the top five medications prescribed for adult acne changed, reflecting differences in available drugs and preferences in treatment approaches by doctors. However, within any individual year, there is considerable overlap among the most commonly prescribed medications and the availability of free samples for those medications. For example, in 2005, the top four most commonly prescribed medications for adult acne were also the top four medications prescribed with a sample.

Lane and Hurley then compared the prescribing patterns of physicians at the academic medical center with those of doctors in the database and calculated the retail price of prescribed medications for a single visit in 2010 for adult acne. They found the average cost of prescriptions for a patient treated by a doctor who received samples was around $465, versus about $200 for patients treated by a doctor without access to samples.

The researchers also found that Lane's original perception of the difference in prescribing patterns between community doctors and those at academic medical center was accurate. Only one of the top 10 medications prescribed at the academic medical center in 2010 was also in the top 10 nationwide. In fact, nine of the 10 most-commonly prescribed medications nationwide for adult acne were branded or branded generics, and only 21 percent of prescriptions written by doctors in the national database were for generic drugs. In contrast, 83 percent of prescriptions from the academic medical center were for generic drugs.

Between 33 and 62 percent of the time, nine of the top 10 nationally prescribed medications were prescribed with samples, although much cheaper generic versions existed for eight of these nine. "The negative consequences of free drug samples affect clinical practice on a national level, and policies should be in place to properly mitigate their inappropriate influence on prescribing patterns," the study says.

The researchers point out that they did not examine patient satisfaction in their study, or rates of adherence to medication regimens (one pill a day of an extended-release branded generic may be easier to stick with than two pills a day of a generic version of the drug, for example). But they urge both patients and physicians to reflect on the purpose of samples and their effect on health-care costs and pharmaceutical profits. At the same time they concede that their findings will likely be unpopular among their peers.

"At one time, we at Stanford really felt that samples were a very important part of our practice," said Lane. "It seemed a good way to help poorer patients, who maybe couldn't afford to pay for medications out-of-pocket, and we had the perception that this was very beneficial for patients. But the important question physicians should be asking themselves now is whether any potential, and as yet unproven, benefit in patient compliance, satisfaction or adherence is really worth the increased cost to patients and the health-care system."


Story Source:

The above story is based on materials provided by Stanford University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael P. Hurley, Randall S. Stafford, Alfred T. Lane. Characterizing the Relationship Between Free Drug Samples and Prescription Patterns for Acne Vulgaris and Rosacea. JAMA Dermatology, 2014; DOI: 10.1001/jamadermatol.2013.9715

Cite This Page:

Stanford University Medical Center. "Dermatologists with access to sample drugs write costlier prescriptions, study finds." ScienceDaily. ScienceDaily, 16 April 2014. <www.sciencedaily.com/releases/2014/04/140416162624.htm>.
Stanford University Medical Center. (2014, April 16). Dermatologists with access to sample drugs write costlier prescriptions, study finds. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/04/140416162624.htm
Stanford University Medical Center. "Dermatologists with access to sample drugs write costlier prescriptions, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/04/140416162624.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins