Featured Research

from universities, journals, and other organizations

Targeting cells resistant to chemotherapy

Date:
April 24, 2014
Source:
Manchester University
Summary:
Scientists have identified a way to sensitize cancer cells to chemotherapy - making them more open to treatment. "Cells replicate and divide through a process known as mitosis. This process is carefully controlled and if any mistake is made during normal division then the cell undergoes apoptosis -- otherwise known as controlled cell death," the team lead said. "Failure of cells to complete mitosis correctly can be the start of cancer. We wanted to understand how this failure -- delay of cell division -- activates apoptosis, and why some cancer cells may be able to avoid being killed."

Scientists from The University of Manchester have identified a way to sensitize cancer cells to chemotherapy -- making them more open to treatment.

The study published today in Cell Reports, could pave the way for the development of drugs to target cells that have become resistant to treatment.

The research team made the discovery whilst exploring the possible mechanisms behind resistance to chemotherapy drugs like Paclitaxel, often used to treat breast and colon cancer.

Dr Andrew Gilmore, who led the research team at The University of Manchester, is part of both the Wellcome Trust Centre for Cell-Matrix Research and also the Manchester Cancer Research Centre.

He said: "Cells replicate and divide through a process known as mitosis. This process is carefully controlled and if any mistake is made during normal division then the cell undergoes apoptosis -- otherwise known as controlled cell death.

"Failure of cells to complete mitosis correctly can be the start of cancer. We wanted to understand how this failure -- delay of cell division -- activates apoptosis, and why some cancer cells may be able to avoid being killed."

Cancer cells replicate rapidly, and chemotherapy drugs such as paclitaxel target mitosis as a way to kill these quickly dividing cells. But cancer cells can develop resistance to the drugs. The researchers found a particular protein known as 'Bid' in colon cancer cells, and looked at what happened when Bid was switched on.

Their results show that Bid is turned on as cells prepare to divide. This primes the cells to die if cell division takes too long. Cancer cells that were resistant to chemotherapy still turned Bid on, but went through mitosis too quickly for it to kill the cell. However, these resistant cells could be made to die by directly targeting the part of the cell where Bid works.

"Our findings demonstrate that Bid plays a central role in mitosis-related cell death. This opens up new areas of research into drugs that might be able to kill cancer cells that have become resistant to chemotherapy. This could eventually be of huge benefit in a clinical setting and help patients who suffer from advanced stages of colon cancer," added Dr Gilmore.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pengbo Wang, Jennefer Lindsay, ThomasW. Owens, EwaJ. Mularczyk, Stacey Warwood, Fiona Foster, CharlesH. Streuli, Keith Brennan, AndrewP. Gilmore. Phosphorylation of the Proapoptotic BH3-Only Protein Bid Primes Mitochondria for Apoptosis during Mitotic Arrest. Cell Reports, 2014; DOI: 10.1016/j.celrep.2014.03.050

Cite This Page:

Manchester University. "Targeting cells resistant to chemotherapy." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424125022.htm>.
Manchester University. (2014, April 24). Targeting cells resistant to chemotherapy. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/04/140424125022.htm
Manchester University. "Targeting cells resistant to chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424125022.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins