Featured Research

from universities, journals, and other organizations

Breakthrough harnesses light for controlled chemical reaction

April 24, 2014
University of Wisconsin-Madison
One catalyst supplies electrons, other one controls position of raw material. Reactions are powered by visible light, not UV. Technique could allow creation of novel molecules for pharmaceuticals.

Sunlight powers a chemical reaction in the window of Tehshik Yoon, a chemistry professor at University of Wisconsin–Madison. Visible light has major advantages for driving reactions, says Yoon, who has invented a new technique for precisely controlling the shape of products powered by light. The technique could be useful in pharmaceuticals, where correct shape is essential.
Credit: Tehshik Yoon

When chemist Tehshik Yoon looks out his office window, he sees a source of energy to drive chemical reactions. Plants "learned" to synthesize chemicals with sunlight eons ago; Yoon came to the field a bit more recently.

Related Articles

But this week, in the journal Science, he and three collaborators detail a way to use sunlight and two catalysts to create molecules that are difficult to make with conventional techniques.

In chemistry, heat and ultraviolet (UV) light are commonly used to drive reactions. Although light can power reactions that heat cannot, UV has disadvantages, says Yoon, a chemistry professor at University of Wisconsin-Madison. The UV often used in industry carries so much energy that "it's dangerous to use, unselective, and prone to making unwanted by-products."

Many chemicals exist in two forms that are mirror images of each other, and Yoon is interested in reactions that make only one of those images.

"It's like your hands," Yoon says. "They are similar, but not identical; a left-hand glove does not fit the right hand. It's the same way with molecules in biology; many fail unless they have the correct 'handedness,' or 'chirality.'"

The pharmaceutical industry, in particular, is concerned about controlling chirality in drugs, but making those shapes is a hit-or-miss proposition with UV light, Yoon says.

He says the new technique answers a question posed by a French chemist in 1874, who suggested using light to make products with controlled chirality. "Chemists could never do that efficiently, and so the prejudice was that it was too difficult to do."

When a graduate student asked for a challenging project seven years ago, Yoon asked him to explore powering reactions compounds with metals that are used to capture the sun's energy in solar cells. In a solar cell, these metals release electrons to make electricity.

"We are taking the electrons that these metals spin out and using their energy to promote a chemical reaction," Yoon says.

Plants do the same thing during photosynthesis, he says: absorb light, release high-energy electrons, and use those electrons to bond water and carbon dioxide into sugars. That reaction is the basis of essentially all of agriculture and all food chains.

Once the solar-cell metal supplied electrons, Yoon thought about using a second catalyst to control chirality. He passed the project to Juana Du, another graduate student.

"She must have synthesized 70 different catalysts," says Yoon. "The great thing about grad students here is that they are so bold. At a certain point I was ready give up; this was so hard I did not know where to go next. Juana went to the literature, made things that had no business working, and they worked beautifully."

To control chirality, the second catalyst held the chemicals under transformation in the correct orientation so the electrons could create only the desired chirality. After graduate student Kazimir Skubi found a way to generalize the control mechanism, Yoon says, post-doctoral fellow Danielle Schultz, "made an interesting discovery: if you make a really small tweak to the chiral control catalyst, you get a completely different shape to the product molecules."

Shultz, Du and Skubi are Yoon's co-authors on the Science paper.

Introducing a second catalyst allowed much greater control, Yoon says.

"One reason this field has failed is that a single catalyst had to both absorb light and control the chirality," says Yoon. "If you tweak the single catalyst, you change its effects. By separating the two roles, you can make all kind of changes to chirality without messing up the photochemical catalyst. To get this to work, two stars have to be aligned."

The experiments to date have made square structures with four carbons that would be difficult to make with UV or heat. Ultimately, Yoon says, the technique may interest material scientists, who are focusing more on chirality, and especially drug makers.

"Drug companies need compounds with well-defined chirality, and they want structures that nobody has made, and we have structures that are really strained, exotic, with controlled chirality," Yoon says. "These are part of an unexplored space in molecular diversity. Now that we have a platform for using these catalysts in tandem, we are looking more broadly to see what else we can do."

Ultimately, Yoon would like to move back to the future and to make chemicals as plants do: powered by sunlight, with all the environmental advantages that implies. It's all in the classic history of photochemistry, Yoon says, pointing to an Italian chemist who advocated powering reactions with sunlight in 1912, and wrote, "… if in a distant future the supply of coal becomes completely exhausted, civilization will not be checked by that, for life and civilization will continue as long as the sun shines!"

Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. The original article was written by David Tenenbaum. Note: Materials may be edited for content and length.

Journal Reference:

  1. J. Du, K. L. Skubi, D. M. Schultz, T. P. Yoon. A Dual-Catalysis Approach to Enantioselective [2 2] Photocycloadditions Using Visible Light. Science, 2014; 344 (6182): 392 DOI: 10.1126/science.1251511

Cite This Page:

University of Wisconsin-Madison. "Breakthrough harnesses light for controlled chemical reaction." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424143653.htm>.
University of Wisconsin-Madison. (2014, April 24). Breakthrough harnesses light for controlled chemical reaction. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2014/04/140424143653.htm
University of Wisconsin-Madison. "Breakthrough harnesses light for controlled chemical reaction." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424143653.htm (accessed March 27, 2015).

Share This

More From ScienceDaily

More Matter & Energy News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations

Featured Videos

from AP, Reuters, AFP, and other news services

Inspectors Found Faulty Work Before NYC Blast

Inspectors Found Faulty Work Before NYC Blast

AP (Mar. 27, 2015) An hour before an apparent gas explosion sent flames soaring and debris flying at a Manhattan apartment building, injuring 19 people, utility company inspectors decided the work being done there was faulty. (March 27) Video provided by AP
Powered by NewsLook.com
Facebook Building Plane-Sized Drones For Global Internet

Facebook Building Plane-Sized Drones For Global Internet

Newsy (Mar. 27, 2015) Facebook on Thursday revealed more details about its Internet-connected drone project. The drone is bigger than a 737, but lighter than a car. Video provided by Newsy
Powered by NewsLook.com
Residents Witness Building Explosion, Collapse

Residents Witness Building Explosion, Collapse

AP (Mar. 26, 2015) Witnesses recount the sites and sounds of a massive explosion and subsequent building collapse in the heart of Manhattan&apos;s trendy East Village on Thursday. (March 26) Video provided by AP
Powered by NewsLook.com
Amazon Complains U.S. Is Too Slow To Regulate Drones

Amazon Complains U.S. Is Too Slow To Regulate Drones

Newsy (Mar. 25, 2015) Days after getting approval to test certain commercial drones, Amazon says the Federal Aviation Administration is dragging its feet on the matter. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.


Breaking News:

Strange & Offbeat Stories

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News


Free Subscriptions

Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile

Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?

Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins