Featured Research

from universities, journals, and other organizations

New diagnostic tool for dementia diseases

Date:
June 5, 2014
Source:
University of Eastern Finland
Summary:
A new diagnostic tool helps clinicians to differentiate between Alzheimer's disease, frontotemporal dementia and mild cognitive impairment. The new method consists of a Disease State Index combining data from multiple sources, and of a Disease State Fingerprint showing the findings in a visual format.

A new diagnostic tool helps clinicians to differentiate between Alzheimer's disease, frontotemporal dementia and mild cognitive impairment. Presented in the doctoral thesis of MD Miguel Ángel Muñoz Ruiz at the University of Eastern Finland, the new method consists of a Disease State Index combining data from multiple sources, and of a Disease State Fingerprint showing the findings in a visual format.

It is estimated that more than 35.6 million people were living with dementia worldwide in 2010. This number will increase in the coming years and there is a need to identify these patients to provide them with proper treatment and care from the very beginning of the disease.

The differential diagnosis of the dementia diseases represents a challenge particularly in the early phases. Many studies have focused on predicting the possible conversion from mild cognitive impairment, a pre-dementia stage, to Alzheimer's disease (AD), the most common dementia disease. Several methods have also been proposed for differentiating between AD and frontotemporal dementia (FTD), another relatively common degenerative dementia. An early and precise diagnosis of these two dementia diseases is needed in order to benefit from treatments designed to influence the disease mechanisms.

In the recent years, important advances have been made especially in the development of new diagnostic methods. Several biomarkers and tests are used in the clinical practice, such as cerebrospinal fluid biomarkers, imaging methods, genetic profiling and neuropsychological tests. However, making a differential diagnosis is not easy due to overlapping clinical and biomarker findings and the unavoidable subjective component when a clinician interprets all this multitude of data. Furthermore, there is no single biomarker or test which could clearly define whether a patient is suffering from AD or FTD.

The thesis of Dr Muñoz Ruiz introduces a new combination of different methods for the differential diagnosis of AD, mild cognitive impairment and FTD, and describes a tool comprising a Disease State Index and its visual counterpart, a Disease State Fingerprint.

The Disease State Index encompasses all the data from multiple sources while taking into account the most relevant method or test, and the Disease State Fingerprint shows the findings in an easy-to-interpret visual format.

The software combines data from multiple sources such as psychological tests and brain MRI, and uses this data to create a Disease State Index. The index is a numerical value between 0 and 1. In a healthy person, the index is close to 0, while an index close to 1 is an indicator of a dementia disease. The Disease State Fingerprint shows the findings in an easy-to-interpret format in which the key findings are clearly indicated by colour and size.

With the help of the new diagnostic tool, clinicians could know which methods are more relevant for profiling a patient with a certain dementia disease, i.e. whether it is mild cognitive impairment, FTD or AD, and already at the first visit, the clinician could make a first diagnosis for starting treatment and giving counselling to the patient.


Story Source:

The above story is based on materials provided by University of Eastern Finland. Note: Materials may be edited for content and length.


Journal References:

  1. Miguel Ángel Muñoz Ruiz et al. Disease Fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment. J Alzheimers Dis., January 2013 DOI: 10.3233/JAD-122260
  2. Miguel Ángel Muñoz-Ruiz, Päivi Hartikainen, Juha Koikkalainen, Robin Wolz, Valtteri Julkunen, Eini Niskanen, Sanna-Kaisa Herukka, Miia Kivipelto, Ritva Vanninen, Daniel Rueckert, Yawu Liu, Jyrki Lötjönen, Hilkka Soininen. Structural MRI in Frontotemporal Dementia: Comparisons between Hippocampal Volumetry, Tensor-Based Morphometry and Voxel-Based Morphometry. PLoS ONE, 2012; 7 (12): e52531 DOI: 10.1371/journal.pone.0052531

Cite This Page:

University of Eastern Finland. "New diagnostic tool for dementia diseases." ScienceDaily. ScienceDaily, 5 June 2014. <www.sciencedaily.com/releases/2014/06/140605100758.htm>.
University of Eastern Finland. (2014, June 5). New diagnostic tool for dementia diseases. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/06/140605100758.htm
University of Eastern Finland. "New diagnostic tool for dementia diseases." ScienceDaily. www.sciencedaily.com/releases/2014/06/140605100758.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins