Featured Research

from universities, journals, and other organizations

Sjögren's Syndrome significantly increases risk of heart attack

Date:
June 13, 2014
Source:
European League Against Rheumatism
Summary:
A new study showed a significantly increased risk of heart attack in patients with Sjögren's syndrome, particularly in the first year following diagnosis. There was also a trend towards an increased risk for stroke.

A new study presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) showed a significantly increased risk of heart attack in patients with Sjögren's syndrome (SjS), particularly in the first year following diagnosis. There was also a trend towards an increased risk for stroke.

SjS is an auto-immune inflammatory disease where the body's immune system attacks glands that secrete fluid, such as the tear and saliva glands. Inflammation within the glands reduces fluid production causing painful burning in the eyes, dry mouth, and sometimes dryness in the nasal passages, throat, vagina and skin. Primary SjS occurs in people with no other rheumatological disease; secondary SjS occurs in people who have another rheumatological disease, most often systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The worldwide prevalence of primary SjS has been estimated at about 0.2% of the adult population, and is thought to affect at least nine times as many women as men.

According to the principal investigator of the study, Dr. Antonio Aviña-Zubieta, a research scientist at the Arthritis Research Centre of Canada and an Assistant Professor of the Department of Medicine -- Division of Rheumatology, University of British Columbia, Vancouver, Canada, "it is the acute inflammatory state in Sjögren's syndrome, particularly at the onset of the disease, which is likely to be the main driver for the increased risk of heart attacks and stroke.

"This is the first general population-based cohort study comparing the relative risk of heart attacks and strokes in patients with new Sjögren's syndrome with age, sex, and entry-matched controls; previously we only had limited data on the relative risks in this specific patient group.

"Our results support the role of inflammation in cardiovascular disease and the need for increased monitoring for coronary artery disease in all patients with this condition, in addition to proper management and modification of their cardiovascular risk factors to reduce the risk of a future heart attack," Dr Aviña-Zubieta the Principal Investigator of the study concluded.

Looking first at the heart attacks, out of 1,176 new cases with SjS, 28 developed a first time heart attack, with an incident rate of 7.7 per 1,000 person-years. Among 11,879 non-SjS matched controls, 138 had a heart attack, with an incident rate of 3.5 per 1,000 person-years.

The results for the stroke cohorts showed that, among 1,195 with new SjS, 19 developed a first-time stroke, with an incident rate of 5.1 per 1,000 person-years. Out of 11,983 non-SjS matched controls, 137 had a CVA event, with an incident rate of 3.4 per 1,000 person-years.

Compared with the age, sex and entry matched controls, the relative risks for heart attack and stroke events were 2.2 (95% CI 1.41- 3.32) and 1.5 (0.9- 2.4), respectively. Adjusting for other relevant risk factors for cardiovascular disease including medications made no significant difference to the relative risk of patients with SjS developing either heart attacks 2.4 (1.5- 3.8) or stroke 1.6 (1.0- 2.8). The risk of developing a heart attack was highest within the first year following diagnosis of SjS (3.6 times), and persisted up to five years following the initial diagnosis. This trend was not seen for strokes.

This was a retrospective matched cohort study with new SjS patients satisfying at least one of the following criteria: diagnosis of SjS (ICD-9-CM code 710.2, ICD-10-CM code M35.0) in adults on at least two visits at least two months apart and within a two-year period between 1996 and 2010 by a non-rheumatologist physician diagnosis of SjS on at least one visit by a rheumatologist or from hospitalisation. cases with diagnostic codes for SjS between 1990 and 1995 were excluded with the intention to select only new SjS cases.

Incident heart attack and stroke events were recorded based on hospitalisation or death certificate. To estimate relative risks, SjS patients were compared with age-, sex- and entry time-matched comparison cohorts, adjusting for potential cardiovascular risk factors. Ten non-SjS controls matched by birth year, sex and calendar year of follow-up were selected from the general population for each case of SjS.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "Sjögren's Syndrome significantly increases risk of heart attack." ScienceDaily. ScienceDaily, 13 June 2014. <www.sciencedaily.com/releases/2014/06/140613084510.htm>.
European League Against Rheumatism. (2014, June 13). Sjögren's Syndrome significantly increases risk of heart attack. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/06/140613084510.htm
European League Against Rheumatism. "Sjögren's Syndrome significantly increases risk of heart attack." ScienceDaily. www.sciencedaily.com/releases/2014/06/140613084510.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins