Featured Research

from universities, journals, and other organizations

Infant toenails reveal in utero exposure to low-level arsenic, study finds

Date:
July 7, 2014
Source:
Dartmouth College
Summary:
Infant toenails are a reliable way to estimate arsenic exposure before birth, a study shows. A growing body of evidence suggests that in utero and early-life exposure to arsenic may have detrimental effects on children, even at the low to moderate levels common in the United States and elsewhere. The fetus starts to develop toenails during the first trimester, making them an accurate measure of exposure to arsenic during the entire gestation.

Infant toenails are a reliable way to estimate arsenic exposure before birth, a Dartmouth College study shows.

The findings appear in the Journal of Exposure Science & Environmental Epidemiology.

A growing body of evidence suggests that in utero and early-life exposure to arsenic may have detrimental effects on children, even at the low to moderate levels common in the United States and elsewhere. The fetus starts to develop toenails during the first trimester, making them an accurate measure of exposure to arsenic during the entire gestation. Prior studies that used infant toenails as a biomarker of in utero exposure were conducted in highly exposed populations.

But in a sample of 170 mother-infant pairs from New Hampshire, the researchers determined infant exposure to relatively low arsenic in utero by evaluating infant toenails as a biomarker using plasma mass spectrometry.

The results show that a doubling of maternal postpartum toenail arsenic concentration was associated with a 54 percent increase in infant toenail arsenic concentration as compared with 20 percent for a doubling of maternal urine arsenic concentration. Also, a doubling of maternal toenail and urine arsenic concentrations was associated with a 68 percent increase in infant toenail arsenic concentration. A similar correlation between infant and maternal postpartum toenail concentrations was observed in a group of 130 mother-infant pairs from Rhode Island.

"In utero exposure to arsenic occurs through maternal drinking water and dietary sources, and infant toenails appear to be a reliable biomarker for estimating arsenic exposure during the critical window of gestation," says senior author Professor Margaret Karagas.


Story Source:

The above story is based on materials provided by Dartmouth College. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthew A Davis, Zhigang Li, Diane Gilbert-Diamond, Todd A Mackenzie, Kathryn L Cottingham, Brian P Jackson, Joyce S Lee, Emily R Baker, Carmen J Marsit, Margaret R Karagas. Infant toenails as a biomarker of in utero arsenic exposure. Journal of Exposure Science and Environmental Epidemiology, 2014; DOI: 10.1038/jes.2014.38

Cite This Page:

Dartmouth College. "Infant toenails reveal in utero exposure to low-level arsenic, study finds." ScienceDaily. ScienceDaily, 7 July 2014. <www.sciencedaily.com/releases/2014/07/140707141714.htm>.
Dartmouth College. (2014, July 7). Infant toenails reveal in utero exposure to low-level arsenic, study finds. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2014/07/140707141714.htm
Dartmouth College. "Infant toenails reveal in utero exposure to low-level arsenic, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/07/140707141714.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins